Recombinant multi-species DAXX protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DAXX protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
The Alternative Names of target: BING2,DAP6,DAXX,Daxx,Daxx (hDaxx),Death domain-associated protein 6,EAP1,ETS1-associated protein 1 (EAP1),Fas death domain-associated protein,SMIM40

Target products collectionGo to DAXX products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP6039-Ag-1/ GM-Tg-hg-IP6039-Ag-2 Human DAXX protein Human
GM-Tg-rg-IP6039-Ag-1/ GM-Tg-rg-IP6039-Ag-2 Rat DAXX protein Rat
GM-Tg-mg-IP6039-Ag-1/ GM-Tg-mg-IP6039-Ag-2 Mouse DAXX protein Mouse
GM-Tg-cynog-IP6039-Ag-1/ GM-Tg-cynog-IP6039-Ag-2 Cynomolgus/Rhesus macaque DAXX protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP6039-Ag-1/ GM-Tg-felg-IP6039-Ag-2 Feline DAXX protein Feline
GM-Tg-cang-IP6039-Ag-1/ GM-Tg-cang-IP6039-Ag-2 Canine DAXX protein Canine
GM-Tg-bovg-IP6039-Ag-1/ GM-Tg-bovg-IP6039-Ag-2 Bovine DAXX protein Bovine
GM-Tg-equg-IP6039-Ag-1/ GM-Tg-equg-IP6039-Ag-2 Equine DAXX protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP6039-Ag-1/ GM-Tg-hg-IP6039-Ag-2; GM-Tg-rg-IP6039-Ag-1/ GM-Tg-rg-IP6039-Ag-2;
GM-Tg-mg-IP6039-Ag-1/ GM-Tg-mg-IP6039-Ag-2; GM-Tg-cynog-IP6039-Ag-1/ GM-Tg-cynog-IP6039-Ag-2;
GM-Tg-felg-IP6039-Ag-1/ GM-Tg-felg-IP6039-Ag-2; GM-Tg-cang-IP6039-Ag-1/ GM-Tg-cang-IP6039-Ag-2;
GM-Tg-bovg-IP6039-Ag-1/ GM-Tg-bovg-IP6039-Ag-2; GM-Tg-equg-IP6039-Ag-1/ GM-Tg-equg-IP6039-Ag-2
Products Name DAXX protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name DAXX
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DAXX protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.