Recombinant multi-species Cystatin B/CSTB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Cystatin B/CSTB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. [provided by RefSeq, Jul 2016]
The Alternative Names of target: CPI-B,CST6,CSTB,Cstb,Cyb,Cystatin B,Cystatin-B,EPM1,EPM1A,Epm1,Liver thiol proteinase inhibitor,PME,STFB,Stefin-B,Stfb,ULD,cystatin-B

Target products collectionGo to Cystatin B/CSTB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP5778-Ag-1/ GM-Tg-hg-IP5778-Ag-2 Human Cystatin B/CSTB protein Human
GM-Tg-rg-IP5778-Ag-1/ GM-Tg-rg-IP5778-Ag-2 Rat Cystatin B/CSTB protein Rat
GM-Tg-mg-IP5778-Ag-1/ GM-Tg-mg-IP5778-Ag-2 Mouse Cystatin B/CSTB protein Mouse
GM-Tg-cynog-IP5778-Ag-1/ GM-Tg-cynog-IP5778-Ag-2 Cynomolgus/Rhesus macaque Cystatin B/CSTB protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP5778-Ag-1/ GM-Tg-felg-IP5778-Ag-2 Feline Cystatin B/CSTB protein Feline
GM-Tg-cang-IP5778-Ag-1/ GM-Tg-cang-IP5778-Ag-2 Canine Cystatin B/CSTB protein Canine
GM-Tg-bovg-IP5778-Ag-1/ GM-Tg-bovg-IP5778-Ag-2 Bovine Cystatin B/CSTB protein Bovine
GM-Tg-equg-IP5778-Ag-1/ GM-Tg-equg-IP5778-Ag-2 Equine Cystatin B/CSTB protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP5778-Ag-1/ GM-Tg-hg-IP5778-Ag-2; GM-Tg-rg-IP5778-Ag-1/ GM-Tg-rg-IP5778-Ag-2;
GM-Tg-mg-IP5778-Ag-1/ GM-Tg-mg-IP5778-Ag-2; GM-Tg-cynog-IP5778-Ag-1/ GM-Tg-cynog-IP5778-Ag-2;
GM-Tg-felg-IP5778-Ag-1/ GM-Tg-felg-IP5778-Ag-2; GM-Tg-cang-IP5778-Ag-1/ GM-Tg-cang-IP5778-Ag-2;
GM-Tg-bovg-IP5778-Ag-1/ GM-Tg-bovg-IP5778-Ag-2; GM-Tg-equg-IP5778-Ag-1/ GM-Tg-equg-IP5778-Ag-2
Products Name Cystatin B/CSTB protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Cystatin B/CSTB
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Cystatin B/CSTB protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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