Recombinant multi-species HOGA1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HOGA1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]
The Alternative Names of target: 0610010D20Rik,4-hydroxy-2-oxoglutarate aldolase,C10orf65,DHDPS2,DHDPSL,Dhdpsl,Dihydrodipicolinate synthase-like (DHDPS-like protein),HOGA1,HP3,Hoga1,NPL2,Npl2,Probable 2-keto-4-hydroxyglutarate aldolase (Probable KHG-aldolase),Protein 569272,RGD1310475,mitochondrial

Target products collectionGo to HOGA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP4099-Ag-1/ GM-Tg-hg-IP4099-Ag-2 Human HOGA1 protein Human
GM-Tg-rg-IP4099-Ag-1/ GM-Tg-rg-IP4099-Ag-2 Rat HOGA1 protein Rat
GM-Tg-mg-IP4099-Ag-1/ GM-Tg-mg-IP4099-Ag-2 Mouse HOGA1 protein Mouse
GM-Tg-cynog-IP4099-Ag-1/ GM-Tg-cynog-IP4099-Ag-2 Cynomolgus/Rhesus macaque HOGA1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP4099-Ag-1/ GM-Tg-felg-IP4099-Ag-2 Feline HOGA1 protein Feline
GM-Tg-cang-IP4099-Ag-1/ GM-Tg-cang-IP4099-Ag-2 Canine HOGA1 protein Canine
GM-Tg-bovg-IP4099-Ag-1/ GM-Tg-bovg-IP4099-Ag-2 Bovine HOGA1 protein Bovine
GM-Tg-equg-IP4099-Ag-1/ GM-Tg-equg-IP4099-Ag-2 Equine HOGA1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP4099-Ag-1/ GM-Tg-hg-IP4099-Ag-2; GM-Tg-rg-IP4099-Ag-1/ GM-Tg-rg-IP4099-Ag-2;
GM-Tg-mg-IP4099-Ag-1/ GM-Tg-mg-IP4099-Ag-2; GM-Tg-cynog-IP4099-Ag-1/ GM-Tg-cynog-IP4099-Ag-2;
GM-Tg-felg-IP4099-Ag-1/ GM-Tg-felg-IP4099-Ag-2; GM-Tg-cang-IP4099-Ag-1/ GM-Tg-cang-IP4099-Ag-2;
GM-Tg-bovg-IP4099-Ag-1/ GM-Tg-bovg-IP4099-Ag-2; GM-Tg-equg-IP4099-Ag-1/ GM-Tg-equg-IP4099-Ag-2
Products Name HOGA1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HOGA1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HOGA1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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