Recombinant multi-species CPSF4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CPSF4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
The Alternative Names of target: 30kDa,CPSF30,CPSF4,Cleavage and polyadenylation specificity factor 30 kDa subunit (CPSF 30 kDa subunit),Cleavage and polyadenylation specificity factor subunit 4,Cpsf4,NAR,NEB-1,NEB1,NS1 effector domain-binding protein 1 (Neb-1),No arches homolog

Target products collectionGo to CPSF4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP3847-Ag-1/ GM-Tg-hg-IP3847-Ag-2 Human CPSF4 protein Human
GM-Tg-rg-IP3847-Ag-1/ GM-Tg-rg-IP3847-Ag-2 Rat CPSF4 protein Rat
GM-Tg-mg-IP3847-Ag-1/ GM-Tg-mg-IP3847-Ag-2 Mouse CPSF4 protein Mouse
GM-Tg-cynog-IP3847-Ag-1/ GM-Tg-cynog-IP3847-Ag-2 Cynomolgus/Rhesus macaque CPSF4 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP3847-Ag-1/ GM-Tg-felg-IP3847-Ag-2 Feline CPSF4 protein Feline
GM-Tg-cang-IP3847-Ag-1/ GM-Tg-cang-IP3847-Ag-2 Canine CPSF4 protein Canine
GM-Tg-bovg-IP3847-Ag-1/ GM-Tg-bovg-IP3847-Ag-2 Bovine CPSF4 protein Bovine
GM-Tg-equg-IP3847-Ag-1/ GM-Tg-equg-IP3847-Ag-2 Equine CPSF4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP3847-Ag-1/ GM-Tg-hg-IP3847-Ag-2; GM-Tg-rg-IP3847-Ag-1/ GM-Tg-rg-IP3847-Ag-2;
GM-Tg-mg-IP3847-Ag-1/ GM-Tg-mg-IP3847-Ag-2; GM-Tg-cynog-IP3847-Ag-1/ GM-Tg-cynog-IP3847-Ag-2;
GM-Tg-felg-IP3847-Ag-1/ GM-Tg-felg-IP3847-Ag-2; GM-Tg-cang-IP3847-Ag-1/ GM-Tg-cang-IP3847-Ag-2;
GM-Tg-bovg-IP3847-Ag-1/ GM-Tg-bovg-IP3847-Ag-2; GM-Tg-equg-IP3847-Ag-1/ GM-Tg-equg-IP3847-Ag-2
Products Name CPSF4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CPSF4
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CPSF4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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