Recombinant multi-species Cofilin/CFL1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Cofilin/CFL1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
The Alternative Names of target: 18 kDa phosphoprotein (p18),CFL,CFL1,Cfl1,Cof,Cofilin,Cofilin-1,HEL-S-15,cofilin,cofilin-1,non-muscle isoform

Target products collectionGo to Cofilin/CFL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP3720-Ag-1/ GM-Tg-hg-IP3720-Ag-2 Human Cofilin/CFL1 protein Human
GM-Tg-rg-IP3720-Ag-1/ GM-Tg-rg-IP3720-Ag-2 Rat Cofilin/CFL1 protein Rat
GM-Tg-mg-IP3720-Ag-1/ GM-Tg-mg-IP3720-Ag-2 Mouse Cofilin/CFL1 protein Mouse
GM-Tg-cynog-IP3720-Ag-1/ GM-Tg-cynog-IP3720-Ag-2 Cynomolgus/Rhesus macaque Cofilin/CFL1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP3720-Ag-1/ GM-Tg-felg-IP3720-Ag-2 Feline Cofilin/CFL1 protein Feline
GM-Tg-cang-IP3720-Ag-1/ GM-Tg-cang-IP3720-Ag-2 Canine Cofilin/CFL1 protein Canine
GM-Tg-bovg-IP3720-Ag-1/ GM-Tg-bovg-IP3720-Ag-2 Bovine Cofilin/CFL1 protein Bovine
GM-Tg-equg-IP3720-Ag-1/ GM-Tg-equg-IP3720-Ag-2 Equine Cofilin/CFL1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP3720-Ag-1/ GM-Tg-hg-IP3720-Ag-2; GM-Tg-rg-IP3720-Ag-1/ GM-Tg-rg-IP3720-Ag-2;
GM-Tg-mg-IP3720-Ag-1/ GM-Tg-mg-IP3720-Ag-2; GM-Tg-cynog-IP3720-Ag-1/ GM-Tg-cynog-IP3720-Ag-2;
GM-Tg-felg-IP3720-Ag-1/ GM-Tg-felg-IP3720-Ag-2; GM-Tg-cang-IP3720-Ag-1/ GM-Tg-cang-IP3720-Ag-2;
GM-Tg-bovg-IP3720-Ag-1/ GM-Tg-bovg-IP3720-Ag-2; GM-Tg-equg-IP3720-Ag-1/ GM-Tg-equg-IP3720-Ag-2
Products Name Cofilin/CFL1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Cofilin/CFL1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Cofilin/CFL1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.