Recombinant multi-species STIL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine STIL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The Alternative Names of target: MCPH7,SCL-interrupting locus protein,SIL,STIL,Sil,Stil,TAL-1-interrupting locus protein

Target products collectionGo to STIL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP2758-Ag-1/ GM-Tg-hg-IP2758-Ag-2 Human STIL protein Human
GM-Tg-rg-IP2758-Ag-1/ GM-Tg-rg-IP2758-Ag-2 Rat STIL protein Rat
GM-Tg-mg-IP2758-Ag-1/ GM-Tg-mg-IP2758-Ag-2 Mouse STIL protein Mouse
GM-Tg-cynog-IP2758-Ag-1/ GM-Tg-cynog-IP2758-Ag-2 Cynomolgus/Rhesus macaque STIL protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP2758-Ag-1/ GM-Tg-felg-IP2758-Ag-2 Feline STIL protein Feline
GM-Tg-cang-IP2758-Ag-1/ GM-Tg-cang-IP2758-Ag-2 Canine STIL protein Canine
GM-Tg-bovg-IP2758-Ag-1/ GM-Tg-bovg-IP2758-Ag-2 Bovine STIL protein Bovine
GM-Tg-equg-IP2758-Ag-1/ GM-Tg-equg-IP2758-Ag-2 Equine STIL protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP2758-Ag-1/ GM-Tg-hg-IP2758-Ag-2; GM-Tg-rg-IP2758-Ag-1/ GM-Tg-rg-IP2758-Ag-2;
GM-Tg-mg-IP2758-Ag-1/ GM-Tg-mg-IP2758-Ag-2; GM-Tg-cynog-IP2758-Ag-1/ GM-Tg-cynog-IP2758-Ag-2;
GM-Tg-felg-IP2758-Ag-1/ GM-Tg-felg-IP2758-Ag-2; GM-Tg-cang-IP2758-Ag-1/ GM-Tg-cang-IP2758-Ag-2;
GM-Tg-bovg-IP2758-Ag-1/ GM-Tg-bovg-IP2758-Ag-2; GM-Tg-equg-IP2758-Ag-1/ GM-Tg-equg-IP2758-Ag-2
Products Name STIL protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name STIL
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine STIL protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.