Recombinant multi-species SMAD1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMAD1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
The Alternative Names of target: BSP-1,BSP1,JV4-1,JV41,MAD homolog 1,MADH1,MADR1,Mad-related protein 1,Mad1,Madh1,Madr1,Mlp1,Mothers against DPP homolog 1,Mothers against decapentaplegic homolog 1,MusMLP,SMAD family member 1 (SMAD 1,SMAD1,Smad1,Transforming growth factor-beta-signaling protein 1 (BSP-1),dwf-A,hSMAD1),mMad1

Target products collectionGo to SMAD1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP2743-Ag-1/ GM-Tg-hg-IP2743-Ag-2 Human SMAD1 protein Human
GM-Tg-rg-IP2743-Ag-1/ GM-Tg-rg-IP2743-Ag-2 Rat SMAD1 protein Rat
GM-Tg-mg-IP2743-Ag-1/ GM-Tg-mg-IP2743-Ag-2 Mouse SMAD1 protein Mouse
GM-Tg-cynog-IP2743-Ag-1/ GM-Tg-cynog-IP2743-Ag-2 Cynomolgus/Rhesus macaque SMAD1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP2743-Ag-1/ GM-Tg-felg-IP2743-Ag-2 Feline SMAD1 protein Feline
GM-Tg-cang-IP2743-Ag-1/ GM-Tg-cang-IP2743-Ag-2 Canine SMAD1 protein Canine
GM-Tg-bovg-IP2743-Ag-1/ GM-Tg-bovg-IP2743-Ag-2 Bovine SMAD1 protein Bovine
GM-Tg-equg-IP2743-Ag-1/ GM-Tg-equg-IP2743-Ag-2 Equine SMAD1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP2743-Ag-1/ GM-Tg-hg-IP2743-Ag-2; GM-Tg-rg-IP2743-Ag-1/ GM-Tg-rg-IP2743-Ag-2;
GM-Tg-mg-IP2743-Ag-1/ GM-Tg-mg-IP2743-Ag-2; GM-Tg-cynog-IP2743-Ag-1/ GM-Tg-cynog-IP2743-Ag-2;
GM-Tg-felg-IP2743-Ag-1/ GM-Tg-felg-IP2743-Ag-2; GM-Tg-cang-IP2743-Ag-1/ GM-Tg-cang-IP2743-Ag-2;
GM-Tg-bovg-IP2743-Ag-1/ GM-Tg-bovg-IP2743-Ag-2; GM-Tg-equg-IP2743-Ag-1/ GM-Tg-equg-IP2743-Ag-2
Products Name SMAD1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SMAD1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMAD1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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