Recombinant multi-species IREB2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IREB2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
The Alternative Names of target: IREB2,Iron-responsive element-binding protein 2,IRE-BP 2,Iron regulatory protein 2 (IRP2),ACO3,IRP2,IRP2AD,NDCAMA,IRE-BP2,IRE-BP 2

Target products collectionGo to IREB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP2550-Ab-1/ GM-Tg-hg-IP2550-Ab-2 Human IREB2 protein Human
GM-Tg-rg-IP2550-Ab-1/ GM-Tg-rg-IP2550-Ab-2 Rat IREB2 protein Rat
GM-Tg-mg-IP2550-Ab-1/ GM-Tg-mg-IP2550-Ab-2 Mouse IREB2 protein Mouse
GM-Tg-cynog-IP2550-Ab-1/ GM-Tg-cynog-IP2550-Ab-2 Cynomolgus/Rhesus macaque IREB2 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP2550-Ab-1/ GM-Tg-felg-IP2550-Ab-2 Feline IREB2 protein Feline
GM-Tg-cang-IP2550-Ab-1/ GM-Tg-cang-IP2550-Ab-2 Canine IREB2 protein Canine
GM-Tg-bovg-IP2550-Ab-1/ GM-Tg-bovg-IP2550-Ab-2 Bovine IREB2 protein Bovine
GM-Tg-equg-IP2550-Ab-1/ GM-Tg-equg-IP2550-Ab-2 Equine IREB2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP2550-Ab-1/ GM-Tg-hg-IP2550-Ab-2; GM-Tg-rg-IP2550-Ab-1/ GM-Tg-rg-IP2550-Ab-2;
GM-Tg-mg-IP2550-Ab-1/ GM-Tg-mg-IP2550-Ab-2; GM-Tg-cynog-IP2550-Ab-1/ GM-Tg-cynog-IP2550-Ab-2;
GM-Tg-felg-IP2550-Ab-1/ GM-Tg-felg-IP2550-Ab-2; GM-Tg-cang-IP2550-Ab-1/ GM-Tg-cang-IP2550-Ab-2;
GM-Tg-bovg-IP2550-Ab-1/ GM-Tg-bovg-IP2550-Ab-2; GM-Tg-equg-IP2550-Ab-1/ GM-Tg-equg-IP2550-Ab-2
Products Name IREB2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IREB2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IREB2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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