Recombinant multi-species ABI1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ABI1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]
The Alternative Names of target: ABI1,Abl interactor 1,Abelson interactor 1 (Abi-1), Abl-binding protein 4 (AblBP4), Eps8 SH3 domain-binding protein (Eps8-binding protein), Nap1-binding protein (Nap1BP), Spectrin SH3 domain-binding protein 1, e3B1,E3B1,ABI-1,ABLBP4,NAP1BP,SSH3BP,SSH3BP1

Target products collectionGo to ABI1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP2328-Ab-1/ GM-Tg-hg-IP2328-Ab-2 Human ABI1 protein Human
GM-Tg-rg-IP2328-Ab-1/ GM-Tg-rg-IP2328-Ab-2 Rat ABI1 protein Rat
GM-Tg-mg-IP2328-Ab-1/ GM-Tg-mg-IP2328-Ab-2 Mouse ABI1 protein Mouse
GM-Tg-cynog-IP2328-Ab-1/ GM-Tg-cynog-IP2328-Ab-2 Cynomolgus/Rhesus macaque ABI1 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP2328-Ab-1/ GM-Tg-felg-IP2328-Ab-2 Feline ABI1 protein Feline
GM-Tg-cang-IP2328-Ab-1/ GM-Tg-cang-IP2328-Ab-2 Canine ABI1 protein Canine
GM-Tg-bovg-IP2328-Ab-1/ GM-Tg-bovg-IP2328-Ab-2 Bovine ABI1 protein Bovine
GM-Tg-equg-IP2328-Ab-1/ GM-Tg-equg-IP2328-Ab-2 Equine ABI1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP2328-Ab-1/ GM-Tg-hg-IP2328-Ab-2; GM-Tg-rg-IP2328-Ab-1/ GM-Tg-rg-IP2328-Ab-2;
GM-Tg-mg-IP2328-Ab-1/ GM-Tg-mg-IP2328-Ab-2; GM-Tg-cynog-IP2328-Ab-1/ GM-Tg-cynog-IP2328-Ab-2;
GM-Tg-felg-IP2328-Ab-1/ GM-Tg-felg-IP2328-Ab-2; GM-Tg-cang-IP2328-Ab-1/ GM-Tg-cang-IP2328-Ab-2;
GM-Tg-bovg-IP2328-Ab-1/ GM-Tg-bovg-IP2328-Ab-2; GM-Tg-equg-IP2328-Ab-1/ GM-Tg-equg-IP2328-Ab-2
Products Name ABI1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ABI1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ABI1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.