Recombinant multi-species TBC1D4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TBC1D4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
The Alternative Names of target: 5930406J04Rik,A930035N22,AS160,Akt substrate of 160 kDa (AS160),As160,NIDDM5,RGD1561609,TBC1 domain family member 4,TBC1D4,Tbc1d4

Target products collectionGo to TBC1D4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP1892-Ag-1/ GM-Tg-hg-IP1892-Ag-2 Human TBC1D4 protein Human
GM-Tg-rg-IP1892-Ag-1/ GM-Tg-rg-IP1892-Ag-2 Rat TBC1D4 protein Rat
GM-Tg-mg-IP1892-Ag-1/ GM-Tg-mg-IP1892-Ag-2 Mouse TBC1D4 protein Mouse
GM-Tg-cynog-IP1892-Ag-1/ GM-Tg-cynog-IP1892-Ag-2 Cynomolgus/Rhesus macaque TBC1D4 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP1892-Ag-1/ GM-Tg-felg-IP1892-Ag-2 Feline TBC1D4 protein Feline
GM-Tg-cang-IP1892-Ag-1/ GM-Tg-cang-IP1892-Ag-2 Canine TBC1D4 protein Canine
GM-Tg-bovg-IP1892-Ag-1/ GM-Tg-bovg-IP1892-Ag-2 Bovine TBC1D4 protein Bovine
GM-Tg-equg-IP1892-Ag-1/ GM-Tg-equg-IP1892-Ag-2 Equine TBC1D4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP1892-Ag-1/ GM-Tg-hg-IP1892-Ag-2; GM-Tg-rg-IP1892-Ag-1/ GM-Tg-rg-IP1892-Ag-2;
GM-Tg-mg-IP1892-Ag-1/ GM-Tg-mg-IP1892-Ag-2; GM-Tg-cynog-IP1892-Ag-1/ GM-Tg-cynog-IP1892-Ag-2;
GM-Tg-felg-IP1892-Ag-1/ GM-Tg-felg-IP1892-Ag-2; GM-Tg-cang-IP1892-Ag-1/ GM-Tg-cang-IP1892-Ag-2;
GM-Tg-bovg-IP1892-Ag-1/ GM-Tg-bovg-IP1892-Ag-2; GM-Tg-equg-IP1892-Ag-1/ GM-Tg-equg-IP1892-Ag-2
Products Name TBC1D4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name TBC1D4
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TBC1D4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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