Recombinant multi-species SMAD2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMAD2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
The Alternative Names of target: 7120426M23Rik,CHTD8,JV18,JV18-1,LDS6,MAD homolog 2,MADH2,MADR2,Mad-related protein 2 (hMAD-2),Madh2,Madr2,Mothers against DPP homolog 2,Mothers against decapentaplegic homolog 2,SMAD family member 2 (SMAD 2,SMAD2,Smad-2,Smad2,hMAD-2,hSMAD2,hSMAD2),mMad2

Target products collectionGo to SMAD2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP1753-Ag-1/ GM-Tg-hg-IP1753-Ag-2 Human SMAD2 protein Human
GM-Tg-rg-IP1753-Ag-1/ GM-Tg-rg-IP1753-Ag-2 Rat SMAD2 protein Rat
GM-Tg-mg-IP1753-Ag-1/ GM-Tg-mg-IP1753-Ag-2 Mouse SMAD2 protein Mouse
GM-Tg-cynog-IP1753-Ag-1/ GM-Tg-cynog-IP1753-Ag-2 Cynomolgus/Rhesus macaque SMAD2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP1753-Ag-1/ GM-Tg-felg-IP1753-Ag-2 Feline SMAD2 protein Feline
GM-Tg-cang-IP1753-Ag-1/ GM-Tg-cang-IP1753-Ag-2 Canine SMAD2 protein Canine
GM-Tg-bovg-IP1753-Ag-1/ GM-Tg-bovg-IP1753-Ag-2 Bovine SMAD2 protein Bovine
GM-Tg-equg-IP1753-Ag-1/ GM-Tg-equg-IP1753-Ag-2 Equine SMAD2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP1753-Ag-1/ GM-Tg-hg-IP1753-Ag-2; GM-Tg-rg-IP1753-Ag-1/ GM-Tg-rg-IP1753-Ag-2;
GM-Tg-mg-IP1753-Ag-1/ GM-Tg-mg-IP1753-Ag-2; GM-Tg-cynog-IP1753-Ag-1/ GM-Tg-cynog-IP1753-Ag-2;
GM-Tg-felg-IP1753-Ag-1/ GM-Tg-felg-IP1753-Ag-2; GM-Tg-cang-IP1753-Ag-1/ GM-Tg-cang-IP1753-Ag-2;
GM-Tg-bovg-IP1753-Ag-1/ GM-Tg-bovg-IP1753-Ag-2; GM-Tg-equg-IP1753-Ag-1/ GM-Tg-equg-IP1753-Ag-2
Products Name SMAD2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SMAD2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMAD2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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