Recombinant multi-species CLOCK protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CLOCK protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
The Alternative Names of target: 5330400M04Rik,CLK,CLOCK,Circadian locomoter output cycles protein kaput,Class E basic helix-loop-helix protein 8 (bHLHe8),Clock,KAT13D,bHLHe8,hCLOCK

Target products collectionGo to CLOCK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP13810-Ag-1/ GM-Tg-hg-IP13810-Ag-2 Human CLOCK protein Human
GM-Tg-rg-IP13810-Ag-1/ GM-Tg-rg-IP13810-Ag-2 Rat CLOCK protein Rat
GM-Tg-mg-IP13810-Ag-1/ GM-Tg-mg-IP13810-Ag-2 Mouse CLOCK protein Mouse
GM-Tg-cynog-IP13810-Ag-1/ GM-Tg-cynog-IP13810-Ag-2 Cynomolgus/Rhesus macaque CLOCK protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP13810-Ag-1/ GM-Tg-felg-IP13810-Ag-2 Feline CLOCK protein Feline
GM-Tg-cang-IP13810-Ag-1/ GM-Tg-cang-IP13810-Ag-2 Canine CLOCK protein Canine
GM-Tg-bovg-IP13810-Ag-1/ GM-Tg-bovg-IP13810-Ag-2 Bovine CLOCK protein Bovine
GM-Tg-equg-IP13810-Ag-1/ GM-Tg-equg-IP13810-Ag-2 Equine CLOCK protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP13810-Ag-1/ GM-Tg-hg-IP13810-Ag-2; GM-Tg-rg-IP13810-Ag-1/ GM-Tg-rg-IP13810-Ag-2;
GM-Tg-mg-IP13810-Ag-1/ GM-Tg-mg-IP13810-Ag-2; GM-Tg-cynog-IP13810-Ag-1/ GM-Tg-cynog-IP13810-Ag-2;
GM-Tg-felg-IP13810-Ag-1/ GM-Tg-felg-IP13810-Ag-2; GM-Tg-cang-IP13810-Ag-1/ GM-Tg-cang-IP13810-Ag-2;
GM-Tg-bovg-IP13810-Ag-1/ GM-Tg-bovg-IP13810-Ag-2; GM-Tg-equg-IP13810-Ag-1/ GM-Tg-equg-IP13810-Ag-2
Products Name CLOCK protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CLOCK
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CLOCK protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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