Recombinant multi-species COX7A2L protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine COX7A2L protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
The Alternative Names of target: COX7A2L,COX7AR,COX7RP,Cox7a2l,Cytochrome c oxidase subunit 7A-related protein (COX7a-related protein),Cytochrome c oxidase subunit 7A2-like,Cytochrome c oxidase subunit VIIa-related protein,EB1,SCAF1,SCAFI,SIG-81,SIG81,Scaf1,Silg81,Supercomplex assembly factor 1,mitochondrial
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Product information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP13550-Ag-1/ GM-Tg-hg-IP13550-Ag-2 | Human COX7A2L protein | Human |
| GM-Tg-rg-IP13550-Ag-1/ GM-Tg-rg-IP13550-Ag-2 | Rat COX7A2L protein | Rat |
| GM-Tg-mg-IP13550-Ag-1/ GM-Tg-mg-IP13550-Ag-2 | Mouse COX7A2L protein | Mouse |
| GM-Tg-cynog-IP13550-Ag-1/ GM-Tg-cynog-IP13550-Ag-2 | Cynomolgus/Rhesus macaque COX7A2L protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP13550-Ag-1/ GM-Tg-felg-IP13550-Ag-2 | Feline COX7A2L protein | Feline |
| GM-Tg-cang-IP13550-Ag-1/ GM-Tg-cang-IP13550-Ag-2 | Canine COX7A2L protein | Canine |
| GM-Tg-bovg-IP13550-Ag-1/ GM-Tg-bovg-IP13550-Ag-2 | Bovine COX7A2L protein | Bovine |
| GM-Tg-equg-IP13550-Ag-1/ GM-Tg-equg-IP13550-Ag-2 | Equine COX7A2L protein | Equine |
Size: 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-IP13550-Ag-1/ GM-Tg-hg-IP13550-Ag-2;
GM-Tg-rg-IP13550-Ag-1/ GM-Tg-rg-IP13550-Ag-2;
GM-Tg-mg-IP13550-Ag-1/ GM-Tg-mg-IP13550-Ag-2; GM-Tg-cynog-IP13550-Ag-1/ GM-Tg-cynog-IP13550-Ag-2; GM-Tg-felg-IP13550-Ag-1/ GM-Tg-felg-IP13550-Ag-2; GM-Tg-cang-IP13550-Ag-1/ GM-Tg-cang-IP13550-Ag-2; GM-Tg-bovg-IP13550-Ag-1/ GM-Tg-bovg-IP13550-Ag-2; GM-Tg-equg-IP13550-Ag-1/ GM-Tg-equg-IP13550-Ag-2 |
| Products Name | COX7A2L protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | COX7A2L |
| Protein Sub-location | Introcelluar Protein |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine COX7A2L protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
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GMab, developed by GeneMedi, constitutes an
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pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.