Recombinant multi-species PHOX2B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PHOX2B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016]
The Alternative Names of target: CCHS,Dilp1,NBLST2,NBPhox,Neuroblastoma Phox (NBPhox),PHOX2B,PHOX2B homeodomain protein,PMX2B,Paired mesoderm homeobox protein 2B,Paired-like homeobox 2B,Phox2b,Pmx2b,Px2b

Target products collectionGo to PHOX2B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP13332-Ag-1/ GM-Tg-hg-IP13332-Ag-2 Human PHOX2B protein Human
GM-Tg-rg-IP13332-Ag-1/ GM-Tg-rg-IP13332-Ag-2 Rat PHOX2B protein Rat
GM-Tg-mg-IP13332-Ag-1/ GM-Tg-mg-IP13332-Ag-2 Mouse PHOX2B protein Mouse
GM-Tg-cynog-IP13332-Ag-1/ GM-Tg-cynog-IP13332-Ag-2 Cynomolgus/Rhesus macaque PHOX2B protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP13332-Ag-1/ GM-Tg-felg-IP13332-Ag-2 Feline PHOX2B protein Feline
GM-Tg-cang-IP13332-Ag-1/ GM-Tg-cang-IP13332-Ag-2 Canine PHOX2B protein Canine
GM-Tg-bovg-IP13332-Ag-1/ GM-Tg-bovg-IP13332-Ag-2 Bovine PHOX2B protein Bovine
GM-Tg-equg-IP13332-Ag-1/ GM-Tg-equg-IP13332-Ag-2 Equine PHOX2B protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP13332-Ag-1/ GM-Tg-hg-IP13332-Ag-2; GM-Tg-rg-IP13332-Ag-1/ GM-Tg-rg-IP13332-Ag-2;
GM-Tg-mg-IP13332-Ag-1/ GM-Tg-mg-IP13332-Ag-2; GM-Tg-cynog-IP13332-Ag-1/ GM-Tg-cynog-IP13332-Ag-2;
GM-Tg-felg-IP13332-Ag-1/ GM-Tg-felg-IP13332-Ag-2; GM-Tg-cang-IP13332-Ag-1/ GM-Tg-cang-IP13332-Ag-2;
GM-Tg-bovg-IP13332-Ag-1/ GM-Tg-bovg-IP13332-Ag-2; GM-Tg-equg-IP13332-Ag-1/ GM-Tg-equg-IP13332-Ag-2
Products Name PHOX2B protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PHOX2B
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PHOX2B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.