Recombinant multi-species BCL10 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BCL10 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
The Alternative Names of target: B-cell CLL/lymphoma 10 (Bcl-10),B-cell lymphoma/leukemia 10,BCL-10,BCL10,Bcl10,CARD-containing molecule enhancing NF-kappa-B,CARD-like apoptotic protein (hCLAP),CARMEN,CED-3/ICH-1 prodomain homologous E10-like regulator (CIPER),CIPER,CLAP,Cellular homolog of vCARMEN (cCARMEN),Cellular-E10 (c-E10),IMD37,ME10,Mammalian CARD-containing adapter molecule E10 (mE10),c-E10,cE10,mE10

Target products collectionGo to BCL10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP13325-Ag-1/ GM-Tg-hg-IP13325-Ag-2 Human BCL10 protein Human
GM-Tg-rg-IP13325-Ag-1/ GM-Tg-rg-IP13325-Ag-2 Rat BCL10 protein Rat
GM-Tg-mg-IP13325-Ag-1/ GM-Tg-mg-IP13325-Ag-2 Mouse BCL10 protein Mouse
GM-Tg-cynog-IP13325-Ag-1/ GM-Tg-cynog-IP13325-Ag-2 Cynomolgus/Rhesus macaque BCL10 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP13325-Ag-1/ GM-Tg-felg-IP13325-Ag-2 Feline BCL10 protein Feline
GM-Tg-cang-IP13325-Ag-1/ GM-Tg-cang-IP13325-Ag-2 Canine BCL10 protein Canine
GM-Tg-bovg-IP13325-Ag-1/ GM-Tg-bovg-IP13325-Ag-2 Bovine BCL10 protein Bovine
GM-Tg-equg-IP13325-Ag-1/ GM-Tg-equg-IP13325-Ag-2 Equine BCL10 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP13325-Ag-1/ GM-Tg-hg-IP13325-Ag-2; GM-Tg-rg-IP13325-Ag-1/ GM-Tg-rg-IP13325-Ag-2;
GM-Tg-mg-IP13325-Ag-1/ GM-Tg-mg-IP13325-Ag-2; GM-Tg-cynog-IP13325-Ag-1/ GM-Tg-cynog-IP13325-Ag-2;
GM-Tg-felg-IP13325-Ag-1/ GM-Tg-felg-IP13325-Ag-2; GM-Tg-cang-IP13325-Ag-1/ GM-Tg-cang-IP13325-Ag-2;
GM-Tg-bovg-IP13325-Ag-1/ GM-Tg-bovg-IP13325-Ag-2; GM-Tg-equg-IP13325-Ag-1/ GM-Tg-equg-IP13325-Ag-2
Products Name BCL10 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name BCL10
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BCL10 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.