Recombinant multi-species SYNGAP1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SYNGAP1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
The Alternative Names of target: Gm1963,MRD5,Neuronal RasGAP,RASA1,RASA5,Ras/Rap GTPase-activating protein SynGAP,SYNGAP,SYNGAP1,Synaptic Ras GTPase-activating protein 1 (Synaptic Ras-GAP 1),Syngap,Syngap1

Target products collectionGo to SYNGAP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP13287-Ag-1/ GM-Tg-hg-IP13287-Ag-2 Human SYNGAP1 protein Human
GM-Tg-rg-IP13287-Ag-1/ GM-Tg-rg-IP13287-Ag-2 Rat SYNGAP1 protein Rat
GM-Tg-mg-IP13287-Ag-1/ GM-Tg-mg-IP13287-Ag-2 Mouse SYNGAP1 protein Mouse
GM-Tg-cynog-IP13287-Ag-1/ GM-Tg-cynog-IP13287-Ag-2 Cynomolgus/Rhesus macaque SYNGAP1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP13287-Ag-1/ GM-Tg-felg-IP13287-Ag-2 Feline SYNGAP1 protein Feline
GM-Tg-cang-IP13287-Ag-1/ GM-Tg-cang-IP13287-Ag-2 Canine SYNGAP1 protein Canine
GM-Tg-bovg-IP13287-Ag-1/ GM-Tg-bovg-IP13287-Ag-2 Bovine SYNGAP1 protein Bovine
GM-Tg-equg-IP13287-Ag-1/ GM-Tg-equg-IP13287-Ag-2 Equine SYNGAP1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP13287-Ag-1/ GM-Tg-hg-IP13287-Ag-2; GM-Tg-rg-IP13287-Ag-1/ GM-Tg-rg-IP13287-Ag-2;
GM-Tg-mg-IP13287-Ag-1/ GM-Tg-mg-IP13287-Ag-2; GM-Tg-cynog-IP13287-Ag-1/ GM-Tg-cynog-IP13287-Ag-2;
GM-Tg-felg-IP13287-Ag-1/ GM-Tg-felg-IP13287-Ag-2; GM-Tg-cang-IP13287-Ag-1/ GM-Tg-cang-IP13287-Ag-2;
GM-Tg-bovg-IP13287-Ag-1/ GM-Tg-bovg-IP13287-Ag-2; GM-Tg-equg-IP13287-Ag-1/ GM-Tg-equg-IP13287-Ag-2
Products Name SYNGAP1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SYNGAP1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SYNGAP1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.