Recombinant multi-species PARL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PARL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]
The Alternative Names of target: D16Ertd607e,Mitochondrial intramembrane cleaving protease PARL,PARL,PRO2207,PSARL,PSARL1,PSENIP2,Parl,Presenilin-associated rhomboid-like protein,Psarl,RHBDS1,mitochondrial

Target products collectionGo to PARL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP1325-Ag-1/ GM-Tg-hg-IP1325-Ag-2 Human PARL protein Human
GM-Tg-rg-IP1325-Ag-1/ GM-Tg-rg-IP1325-Ag-2 Rat PARL protein Rat
GM-Tg-mg-IP1325-Ag-1/ GM-Tg-mg-IP1325-Ag-2 Mouse PARL protein Mouse
GM-Tg-cynog-IP1325-Ag-1/ GM-Tg-cynog-IP1325-Ag-2 Cynomolgus/Rhesus macaque PARL protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP1325-Ag-1/ GM-Tg-felg-IP1325-Ag-2 Feline PARL protein Feline
GM-Tg-cang-IP1325-Ag-1/ GM-Tg-cang-IP1325-Ag-2 Canine PARL protein Canine
GM-Tg-bovg-IP1325-Ag-1/ GM-Tg-bovg-IP1325-Ag-2 Bovine PARL protein Bovine
GM-Tg-equg-IP1325-Ag-1/ GM-Tg-equg-IP1325-Ag-2 Equine PARL protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP1325-Ag-1/ GM-Tg-hg-IP1325-Ag-2; GM-Tg-rg-IP1325-Ag-1/ GM-Tg-rg-IP1325-Ag-2;
GM-Tg-mg-IP1325-Ag-1/ GM-Tg-mg-IP1325-Ag-2; GM-Tg-cynog-IP1325-Ag-1/ GM-Tg-cynog-IP1325-Ag-2;
GM-Tg-felg-IP1325-Ag-1/ GM-Tg-felg-IP1325-Ag-2; GM-Tg-cang-IP1325-Ag-1/ GM-Tg-cang-IP1325-Ag-2;
GM-Tg-bovg-IP1325-Ag-1/ GM-Tg-bovg-IP1325-Ag-2; GM-Tg-equg-IP1325-Ag-1/ GM-Tg-equg-IP1325-Ag-2
Products Name PARL protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PARL
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PARL protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.