Recombinant multi-species CBFB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CBFB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The Alternative Names of target: CBF-beta,CBFB,CBFb-2,CLCD2,Cbfb,Core-binding factor subunit beta,PEA2,PEBP2-beta),PEBP2B,PEBP2b,Pebp2,Pebpb2,Polyomavirus enhancer-binding protein 2 beta subunit (PEA2-beta,SL3-3 enhancer factor 1 subunit beta,SL3/AKV core-binding factor beta subunit

Target products collectionGo to CBFB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP13229-Ag-1/ GM-Tg-hg-IP13229-Ag-2 Human CBFB protein Human
GM-Tg-rg-IP13229-Ag-1/ GM-Tg-rg-IP13229-Ag-2 Rat CBFB protein Rat
GM-Tg-mg-IP13229-Ag-1/ GM-Tg-mg-IP13229-Ag-2 Mouse CBFB protein Mouse
GM-Tg-cynog-IP13229-Ag-1/ GM-Tg-cynog-IP13229-Ag-2 Cynomolgus/Rhesus macaque CBFB protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP13229-Ag-1/ GM-Tg-felg-IP13229-Ag-2 Feline CBFB protein Feline
GM-Tg-cang-IP13229-Ag-1/ GM-Tg-cang-IP13229-Ag-2 Canine CBFB protein Canine
GM-Tg-bovg-IP13229-Ag-1/ GM-Tg-bovg-IP13229-Ag-2 Bovine CBFB protein Bovine
GM-Tg-equg-IP13229-Ag-1/ GM-Tg-equg-IP13229-Ag-2 Equine CBFB protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP13229-Ag-1/ GM-Tg-hg-IP13229-Ag-2; GM-Tg-rg-IP13229-Ag-1/ GM-Tg-rg-IP13229-Ag-2;
GM-Tg-mg-IP13229-Ag-1/ GM-Tg-mg-IP13229-Ag-2; GM-Tg-cynog-IP13229-Ag-1/ GM-Tg-cynog-IP13229-Ag-2;
GM-Tg-felg-IP13229-Ag-1/ GM-Tg-felg-IP13229-Ag-2; GM-Tg-cang-IP13229-Ag-1/ GM-Tg-cang-IP13229-Ag-2;
GM-Tg-bovg-IP13229-Ag-1/ GM-Tg-bovg-IP13229-Ag-2; GM-Tg-equg-IP13229-Ag-1/ GM-Tg-equg-IP13229-Ag-2
Products Name CBFB protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CBFB
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CBFB protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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