Recombinant multi-species MAML2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MAML2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
The Alternative Names of target: 5930431H10,MAM-3,MAM2,MAM3,MAML2,MLL-MAML2,Mam-2,Maml2,Mastermind-like protein 2

Target products collectionGo to MAML2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP12930-Ag-1/ GM-Tg-hg-IP12930-Ag-2 Human MAML2 protein Human
GM-Tg-rg-IP12930-Ag-1/ GM-Tg-rg-IP12930-Ag-2 Rat MAML2 protein Rat
GM-Tg-mg-IP12930-Ag-1/ GM-Tg-mg-IP12930-Ag-2 Mouse MAML2 protein Mouse
GM-Tg-cynog-IP12930-Ag-1/ GM-Tg-cynog-IP12930-Ag-2 Cynomolgus/Rhesus macaque MAML2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP12930-Ag-1/ GM-Tg-felg-IP12930-Ag-2 Feline MAML2 protein Feline
GM-Tg-cang-IP12930-Ag-1/ GM-Tg-cang-IP12930-Ag-2 Canine MAML2 protein Canine
GM-Tg-bovg-IP12930-Ag-1/ GM-Tg-bovg-IP12930-Ag-2 Bovine MAML2 protein Bovine
GM-Tg-equg-IP12930-Ag-1/ GM-Tg-equg-IP12930-Ag-2 Equine MAML2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP12930-Ag-1/ GM-Tg-hg-IP12930-Ag-2; GM-Tg-rg-IP12930-Ag-1/ GM-Tg-rg-IP12930-Ag-2;
GM-Tg-mg-IP12930-Ag-1/ GM-Tg-mg-IP12930-Ag-2; GM-Tg-cynog-IP12930-Ag-1/ GM-Tg-cynog-IP12930-Ag-2;
GM-Tg-felg-IP12930-Ag-1/ GM-Tg-felg-IP12930-Ag-2; GM-Tg-cang-IP12930-Ag-1/ GM-Tg-cang-IP12930-Ag-2;
GM-Tg-bovg-IP12930-Ag-1/ GM-Tg-bovg-IP12930-Ag-2; GM-Tg-equg-IP12930-Ag-1/ GM-Tg-equg-IP12930-Ag-2
Products Name MAML2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MAML2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MAML2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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