Recombinant multi-species CARD11 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CARD11 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]
The Alternative Names of target: 0610008L17Rik,2410011D02Rik,BENTA,BIMP3,CARD-containing MAGUK protein 1 (Carma 1),CARD11,CARMA1,Card11,Caspase recruitment domain-containing protein 11,IMD11,IMD11A,PPBL
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Product information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP12925-Ag-1/ GM-Tg-hg-IP12925-Ag-2 | Human CARD11 protein | Human |
| GM-Tg-rg-IP12925-Ag-1/ GM-Tg-rg-IP12925-Ag-2 | Rat CARD11 protein | Rat |
| GM-Tg-mg-IP12925-Ag-1/ GM-Tg-mg-IP12925-Ag-2 | Mouse CARD11 protein | Mouse |
| GM-Tg-cynog-IP12925-Ag-1/ GM-Tg-cynog-IP12925-Ag-2 | Cynomolgus/Rhesus macaque CARD11 protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP12925-Ag-1/ GM-Tg-felg-IP12925-Ag-2 | Feline CARD11 protein | Feline |
| GM-Tg-cang-IP12925-Ag-1/ GM-Tg-cang-IP12925-Ag-2 | Canine CARD11 protein | Canine |
| GM-Tg-bovg-IP12925-Ag-1/ GM-Tg-bovg-IP12925-Ag-2 | Bovine CARD11 protein | Bovine |
| GM-Tg-equg-IP12925-Ag-1/ GM-Tg-equg-IP12925-Ag-2 | Equine CARD11 protein | Equine |
Size: 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-IP12925-Ag-1/ GM-Tg-hg-IP12925-Ag-2;
GM-Tg-rg-IP12925-Ag-1/ GM-Tg-rg-IP12925-Ag-2;
GM-Tg-mg-IP12925-Ag-1/ GM-Tg-mg-IP12925-Ag-2; GM-Tg-cynog-IP12925-Ag-1/ GM-Tg-cynog-IP12925-Ag-2; GM-Tg-felg-IP12925-Ag-1/ GM-Tg-felg-IP12925-Ag-2; GM-Tg-cang-IP12925-Ag-1/ GM-Tg-cang-IP12925-Ag-2; GM-Tg-bovg-IP12925-Ag-1/ GM-Tg-bovg-IP12925-Ag-2; GM-Tg-equg-IP12925-Ag-1/ GM-Tg-equg-IP12925-Ag-2 |
| Products Name | CARD11 protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | CARD11 |
| Protein Sub-location | Introcelluar Protein |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CARD11 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
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GMab, developed by GeneMedi, constitutes an
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strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.