Recombinant multi-species Histone H4/H4C5 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Histone H4/H4C5 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
The Alternative Names of target: H4-16,H4/j,H4C1,H4C11,H4C12,H4C13,H4C14,H4C15,H4C16,H4C2,H4C3,H4C4,H4C5,H4C6,H4C8,H4C9,H4FJ,HIST1H4E,Histone H4,TEBIVANED3,TEVANED3
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Product information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP12719-Ag-1/ GM-Tg-hg-IP12719-Ag-2 | Human Histone H4/H4C5 protein | Human |
| GM-Tg-rg-IP12719-Ag-1/ GM-Tg-rg-IP12719-Ag-2 | Rat Histone H4/H4C5 protein | Rat |
| GM-Tg-mg-IP12719-Ag-1/ GM-Tg-mg-IP12719-Ag-2 | Mouse Histone H4/H4C5 protein | Mouse |
| GM-Tg-cynog-IP12719-Ag-1/ GM-Tg-cynog-IP12719-Ag-2 | Cynomolgus/Rhesus macaque Histone H4/H4C5 protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP12719-Ag-1/ GM-Tg-felg-IP12719-Ag-2 | Feline Histone H4/H4C5 protein | Feline |
| GM-Tg-cang-IP12719-Ag-1/ GM-Tg-cang-IP12719-Ag-2 | Canine Histone H4/H4C5 protein | Canine |
| GM-Tg-bovg-IP12719-Ag-1/ GM-Tg-bovg-IP12719-Ag-2 | Bovine Histone H4/H4C5 protein | Bovine |
| GM-Tg-equg-IP12719-Ag-1/ GM-Tg-equg-IP12719-Ag-2 | Equine Histone H4/H4C5 protein | Equine |
Size: 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-IP12719-Ag-1/ GM-Tg-hg-IP12719-Ag-2;
GM-Tg-rg-IP12719-Ag-1/ GM-Tg-rg-IP12719-Ag-2;
GM-Tg-mg-IP12719-Ag-1/ GM-Tg-mg-IP12719-Ag-2; GM-Tg-cynog-IP12719-Ag-1/ GM-Tg-cynog-IP12719-Ag-2; GM-Tg-felg-IP12719-Ag-1/ GM-Tg-felg-IP12719-Ag-2; GM-Tg-cang-IP12719-Ag-1/ GM-Tg-cang-IP12719-Ag-2; GM-Tg-bovg-IP12719-Ag-1/ GM-Tg-bovg-IP12719-Ag-2; GM-Tg-equg-IP12719-Ag-1/ GM-Tg-equg-IP12719-Ag-2 |
| Products Name | Histone H4/H4C5 protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | Histone H4/H4C5 |
| Protein Sub-location | Introcelluar Protein |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Histone H4/H4C5 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
About Gmab

GMab, developed by GeneMedi, constitutes an
advanced library of recombinant
monoclonal antibodies, each meticulously
designed to target specific molecular
entities. Leveraging the sophisticated
capabilities of GM’s Taurus™ and LIBRA™
platforms, GMab synthesizes antibodies
characterized by high binding affinity,
exceptional physicochemical stability, and
optimal developability profiles.
Through
expression in mammalian cell lines, GMab has
been established as a paradigmatic
reference antibody. It holds significance in
myriad domains of biological drug
discovery, encompassing cellular cultivation,
innovative assay methodologies,
strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.