Recombinant multi-species HIST1H3A/Histone H3/H3C1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HIST1H3A/Histone H3/H3C1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
The Alternative Names of target: H3/A,H3C1,H3C10,H3C11,H3C12,H3C2,H3C3,H3C4,H3C6,H3C7,H3C8,H3FA,H3c1,H3c10,H3c11,H3c8,HIST1H3A,Hist1h3a,Histone H3,Histone H3.1,Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l

Target products collectionGo to HIST1H3A/Histone H3/H3C1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP12677-Ag-1/ GM-Tg-hg-IP12677-Ag-2 Human HIST1H3A/Histone H3/H3C1 protein Human
GM-Tg-rg-IP12677-Ag-1/ GM-Tg-rg-IP12677-Ag-2 Rat HIST1H3A/Histone H3/H3C1 protein Rat
GM-Tg-mg-IP12677-Ag-1/ GM-Tg-mg-IP12677-Ag-2 Mouse HIST1H3A/Histone H3/H3C1 protein Mouse
GM-Tg-cynog-IP12677-Ag-1/ GM-Tg-cynog-IP12677-Ag-2 Cynomolgus/Rhesus macaque HIST1H3A/Histone H3/H3C1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP12677-Ag-1/ GM-Tg-felg-IP12677-Ag-2 Feline HIST1H3A/Histone H3/H3C1 protein Feline
GM-Tg-cang-IP12677-Ag-1/ GM-Tg-cang-IP12677-Ag-2 Canine HIST1H3A/Histone H3/H3C1 protein Canine
GM-Tg-bovg-IP12677-Ag-1/ GM-Tg-bovg-IP12677-Ag-2 Bovine HIST1H3A/Histone H3/H3C1 protein Bovine
GM-Tg-equg-IP12677-Ag-1/ GM-Tg-equg-IP12677-Ag-2 Equine HIST1H3A/Histone H3/H3C1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP12677-Ag-1/ GM-Tg-hg-IP12677-Ag-2; GM-Tg-rg-IP12677-Ag-1/ GM-Tg-rg-IP12677-Ag-2;
GM-Tg-mg-IP12677-Ag-1/ GM-Tg-mg-IP12677-Ag-2; GM-Tg-cynog-IP12677-Ag-1/ GM-Tg-cynog-IP12677-Ag-2;
GM-Tg-felg-IP12677-Ag-1/ GM-Tg-felg-IP12677-Ag-2; GM-Tg-cang-IP12677-Ag-1/ GM-Tg-cang-IP12677-Ag-2;
GM-Tg-bovg-IP12677-Ag-1/ GM-Tg-bovg-IP12677-Ag-2; GM-Tg-equg-IP12677-Ag-1/ GM-Tg-equg-IP12677-Ag-2
Products Name HIST1H3A/Histone H3/H3C1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HIST1H3A/Histone H3/H3C1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HIST1H3A/Histone H3/H3C1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.