Recombinant multi-species SMC1A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMC1A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
The Alternative Names of target: 5830426I24Rik,CDLS2,DEE85,DXS423E,EIEE85,SB1.8,SMC protein 1A,SMC-1-alpha,SMC-1A,SMC1,SMC1A,SMC1L1,SMC1alpha,SMCB,Sb1.8,Smc1,Smc1a,Smc1alpha,Smc1l1,Smcb,Structural maintenance of chromosomes protein 1A,mKIAA0178

Target products collectionGo to SMC1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP12614-Ag-1/ GM-Tg-hg-IP12614-Ag-2 Human SMC1A protein Human
GM-Tg-rg-IP12614-Ag-1/ GM-Tg-rg-IP12614-Ag-2 Rat SMC1A protein Rat
GM-Tg-mg-IP12614-Ag-1/ GM-Tg-mg-IP12614-Ag-2 Mouse SMC1A protein Mouse
GM-Tg-cynog-IP12614-Ag-1/ GM-Tg-cynog-IP12614-Ag-2 Cynomolgus/Rhesus macaque SMC1A protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP12614-Ag-1/ GM-Tg-felg-IP12614-Ag-2 Feline SMC1A protein Feline
GM-Tg-cang-IP12614-Ag-1/ GM-Tg-cang-IP12614-Ag-2 Canine SMC1A protein Canine
GM-Tg-bovg-IP12614-Ag-1/ GM-Tg-bovg-IP12614-Ag-2 Bovine SMC1A protein Bovine
GM-Tg-equg-IP12614-Ag-1/ GM-Tg-equg-IP12614-Ag-2 Equine SMC1A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP12614-Ag-1/ GM-Tg-hg-IP12614-Ag-2; GM-Tg-rg-IP12614-Ag-1/ GM-Tg-rg-IP12614-Ag-2;
GM-Tg-mg-IP12614-Ag-1/ GM-Tg-mg-IP12614-Ag-2; GM-Tg-cynog-IP12614-Ag-1/ GM-Tg-cynog-IP12614-Ag-2;
GM-Tg-felg-IP12614-Ag-1/ GM-Tg-felg-IP12614-Ag-2; GM-Tg-cang-IP12614-Ag-1/ GM-Tg-cang-IP12614-Ag-2;
GM-Tg-bovg-IP12614-Ag-1/ GM-Tg-bovg-IP12614-Ag-2; GM-Tg-equg-IP12614-Ag-1/ GM-Tg-equg-IP12614-Ag-2
Products Name SMC1A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SMC1A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMC1A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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