Recombinant multi-species FIP1L1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FIP1L1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
The Alternative Names of target: 1300019H17Rik,FIP1,FIP1-like 1 protein,FIP1L1,Factor interacting with PAP,Fip1l1,Pre-mRNA 3'-end-processing factor FIP1,Rearranged in hypereosinophilia,Rhe,Rje,hFip1

Target products collectionGo to FIP1L1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP12555-Ag-1/ GM-Tg-hg-IP12555-Ag-2 Human FIP1L1 protein Human
GM-Tg-rg-IP12555-Ag-1/ GM-Tg-rg-IP12555-Ag-2 Rat FIP1L1 protein Rat
GM-Tg-mg-IP12555-Ag-1/ GM-Tg-mg-IP12555-Ag-2 Mouse FIP1L1 protein Mouse
GM-Tg-cynog-IP12555-Ag-1/ GM-Tg-cynog-IP12555-Ag-2 Cynomolgus/Rhesus macaque FIP1L1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP12555-Ag-1/ GM-Tg-felg-IP12555-Ag-2 Feline FIP1L1 protein Feline
GM-Tg-cang-IP12555-Ag-1/ GM-Tg-cang-IP12555-Ag-2 Canine FIP1L1 protein Canine
GM-Tg-bovg-IP12555-Ag-1/ GM-Tg-bovg-IP12555-Ag-2 Bovine FIP1L1 protein Bovine
GM-Tg-equg-IP12555-Ag-1/ GM-Tg-equg-IP12555-Ag-2 Equine FIP1L1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP12555-Ag-1/ GM-Tg-hg-IP12555-Ag-2; GM-Tg-rg-IP12555-Ag-1/ GM-Tg-rg-IP12555-Ag-2;
GM-Tg-mg-IP12555-Ag-1/ GM-Tg-mg-IP12555-Ag-2; GM-Tg-cynog-IP12555-Ag-1/ GM-Tg-cynog-IP12555-Ag-2;
GM-Tg-felg-IP12555-Ag-1/ GM-Tg-felg-IP12555-Ag-2; GM-Tg-cang-IP12555-Ag-1/ GM-Tg-cang-IP12555-Ag-2;
GM-Tg-bovg-IP12555-Ag-1/ GM-Tg-bovg-IP12555-Ag-2; GM-Tg-equg-IP12555-Ag-1/ GM-Tg-equg-IP12555-Ag-2
Products Name FIP1L1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name FIP1L1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FIP1L1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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