Recombinant multi-species NUP214 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NUP214 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
The Alternative Names of target: 214 kDa nucleoporin,CAIN,CAN,D2H9S46E,IIAE9,NUP214,Nuclear pore complex protein Nup214,Nucleoporin Nup214,Nup214,Protein CAN,RGD1304977
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Product information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP12427-Ag-1/ GM-Tg-hg-IP12427-Ag-2 | Human NUP214 protein | Human |
| GM-Tg-rg-IP12427-Ag-1/ GM-Tg-rg-IP12427-Ag-2 | Rat NUP214 protein | Rat |
| GM-Tg-mg-IP12427-Ag-1/ GM-Tg-mg-IP12427-Ag-2 | Mouse NUP214 protein | Mouse |
| GM-Tg-cynog-IP12427-Ag-1/ GM-Tg-cynog-IP12427-Ag-2 | Cynomolgus/Rhesus macaque NUP214 protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP12427-Ag-1/ GM-Tg-felg-IP12427-Ag-2 | Feline NUP214 protein | Feline |
| GM-Tg-cang-IP12427-Ag-1/ GM-Tg-cang-IP12427-Ag-2 | Canine NUP214 protein | Canine |
| GM-Tg-bovg-IP12427-Ag-1/ GM-Tg-bovg-IP12427-Ag-2 | Bovine NUP214 protein | Bovine |
| GM-Tg-equg-IP12427-Ag-1/ GM-Tg-equg-IP12427-Ag-2 | Equine NUP214 protein | Equine |
Size: 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-IP12427-Ag-1/ GM-Tg-hg-IP12427-Ag-2;
GM-Tg-rg-IP12427-Ag-1/ GM-Tg-rg-IP12427-Ag-2;
GM-Tg-mg-IP12427-Ag-1/ GM-Tg-mg-IP12427-Ag-2; GM-Tg-cynog-IP12427-Ag-1/ GM-Tg-cynog-IP12427-Ag-2; GM-Tg-felg-IP12427-Ag-1/ GM-Tg-felg-IP12427-Ag-2; GM-Tg-cang-IP12427-Ag-1/ GM-Tg-cang-IP12427-Ag-2; GM-Tg-bovg-IP12427-Ag-1/ GM-Tg-bovg-IP12427-Ag-2; GM-Tg-equg-IP12427-Ag-1/ GM-Tg-equg-IP12427-Ag-2 |
| Products Name | NUP214 protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | NUP214 |
| Protein Sub-location | Introcelluar Protein |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NUP214 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
About Gmab

GMab, developed by GeneMedi, constitutes an
advanced library of recombinant
monoclonal antibodies, each meticulously
designed to target specific molecular
entities. Leveraging the sophisticated
capabilities of GM’s Taurus™ and LIBRA™
platforms, GMab synthesizes antibodies
characterized by high binding affinity,
exceptional physicochemical stability, and
optimal developability profiles.
Through
expression in mammalian cell lines, GMab has
been established as a paradigmatic
reference antibody. It holds significance in
myriad domains of biological drug
discovery, encompassing cellular cultivation,
innovative assay methodologies,
strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.