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Recombinant multi-species 14-3-3E/14-3-3 Epsilon/YWHAE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine 14-3-3E/14-3-3 Epsilon/YWHAE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
The Alternative Names of target: 14-3-3 Epsilon,14-3-3 protein epsilon,14-3-3E,14-3-3e,HEL2,KCIP-1,MDCR,MDS,YWHAE,Ywhae
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(antibodies,
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MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP11939-Ag-1/ GM-Tg-hg-IP11939-Ag-2 | Human 14-3-3E/14-3-3 Epsilon/YWHAE protein | Human |
| GM-Tg-rg-IP11939-Ag-1/ GM-Tg-rg-IP11939-Ag-2 | Rat 14-3-3E/14-3-3 Epsilon/YWHAE protein | Rat |
| GM-Tg-mg-IP11939-Ag-1/ GM-Tg-mg-IP11939-Ag-2 | Mouse 14-3-3E/14-3-3 Epsilon/YWHAE protein | Mouse |
| GM-Tg-cynog-IP11939-Ag-1/ GM-Tg-cynog-IP11939-Ag-2 | Cynomolgus/Rhesus macaque 14-3-3E/14-3-3 Epsilon/YWHAE protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP11939-Ag-1/ GM-Tg-felg-IP11939-Ag-2 | Feline 14-3-3E/14-3-3 Epsilon/YWHAE protein | Feline |
| GM-Tg-cang-IP11939-Ag-1/ GM-Tg-cang-IP11939-Ag-2 | Canine 14-3-3E/14-3-3 Epsilon/YWHAE protein | Canine |
| GM-Tg-bovg-IP11939-Ag-1/ GM-Tg-bovg-IP11939-Ag-2 | Bovine 14-3-3E/14-3-3 Epsilon/YWHAE protein | Bovine |
| GM-Tg-equg-IP11939-Ag-1/ GM-Tg-equg-IP11939-Ag-2 | Equine 14-3-3E/14-3-3 Epsilon/YWHAE protein | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-IP11939-Ag-1/ GM-Tg-hg-IP11939-Ag-2;
GM-Tg-rg-IP11939-Ag-1/ GM-Tg-rg-IP11939-Ag-2;
GM-Tg-mg-IP11939-Ag-1/ GM-Tg-mg-IP11939-Ag-2; GM-Tg-cynog-IP11939-Ag-1/ GM-Tg-cynog-IP11939-Ag-2; GM-Tg-felg-IP11939-Ag-1/ GM-Tg-felg-IP11939-Ag-2; GM-Tg-cang-IP11939-Ag-1/ GM-Tg-cang-IP11939-Ag-2; GM-Tg-bovg-IP11939-Ag-1/ GM-Tg-bovg-IP11939-Ag-2; GM-Tg-equg-IP11939-Ag-1/ GM-Tg-equg-IP11939-Ag-2 |
| Products Name | 14-3-3E/14-3-3 Epsilon/YWHAE protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | 14-3-3E/14-3-3 Epsilon/YWHAE |
| Protein Sub-location | Introcelluar Protein |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine 14-3-3E/14-3-3 Epsilon/YWHAE protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
About Gmab
GMab, developed by GeneMedi, constitutes an
advanced library of recombinant
monoclonal antibodies, each meticulously
designed to target specific molecular
entities. Leveraging the sophisticated
capabilities of GM’s Taurus™ and LIBRA™
platforms, GMab synthesizes antibodies
characterized by high binding affinity,
exceptional physicochemical stability, and
optimal developability profiles.
Through
expression in mammalian cell lines, GMab has
been established as a paradigmatic
reference antibody. It holds significance in
myriad domains of biological drug
discovery, encompassing cellular cultivation,
innovative assay methodologies,
strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.