Recombinant multi-species VAV1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine VAV1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
The Alternative Names of target: Proto-oncogene vav,VAV,VAV1,Vav,Vav1,vav-T

Target products collectionGo to VAV1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP11918-Ag-1/ GM-Tg-hg-IP11918-Ag-2 Human VAV1 protein Human
GM-Tg-rg-IP11918-Ag-1/ GM-Tg-rg-IP11918-Ag-2 Rat VAV1 protein Rat
GM-Tg-mg-IP11918-Ag-1/ GM-Tg-mg-IP11918-Ag-2 Mouse VAV1 protein Mouse
GM-Tg-cynog-IP11918-Ag-1/ GM-Tg-cynog-IP11918-Ag-2 Cynomolgus/Rhesus macaque VAV1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP11918-Ag-1/ GM-Tg-felg-IP11918-Ag-2 Feline VAV1 protein Feline
GM-Tg-cang-IP11918-Ag-1/ GM-Tg-cang-IP11918-Ag-2 Canine VAV1 protein Canine
GM-Tg-bovg-IP11918-Ag-1/ GM-Tg-bovg-IP11918-Ag-2 Bovine VAV1 protein Bovine
GM-Tg-equg-IP11918-Ag-1/ GM-Tg-equg-IP11918-Ag-2 Equine VAV1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP11918-Ag-1/ GM-Tg-hg-IP11918-Ag-2; GM-Tg-rg-IP11918-Ag-1/ GM-Tg-rg-IP11918-Ag-2;
GM-Tg-mg-IP11918-Ag-1/ GM-Tg-mg-IP11918-Ag-2; GM-Tg-cynog-IP11918-Ag-1/ GM-Tg-cynog-IP11918-Ag-2;
GM-Tg-felg-IP11918-Ag-1/ GM-Tg-felg-IP11918-Ag-2; GM-Tg-cang-IP11918-Ag-1/ GM-Tg-cang-IP11918-Ag-2;
GM-Tg-bovg-IP11918-Ag-1/ GM-Tg-bovg-IP11918-Ag-2; GM-Tg-equg-IP11918-Ag-1/ GM-Tg-equg-IP11918-Ag-2
Products Name VAV1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name VAV1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine VAV1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.