Recombinant multi-species ubiquitin/UBB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ubiquitin/UBB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
The Alternative Names of target: HEL-S-50,Polyubiquitin-B,Rps27a,UBB,UBC,Uba52,Ubb,Ubb2,Ubc,ubiquitin

Target products collectionGo to ubiquitin/UBB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP11888-Ag-1/ GM-Tg-hg-IP11888-Ag-2 Human ubiquitin/UBB protein Human
GM-Tg-rg-IP11888-Ag-1/ GM-Tg-rg-IP11888-Ag-2 Rat ubiquitin/UBB protein Rat
GM-Tg-mg-IP11888-Ag-1/ GM-Tg-mg-IP11888-Ag-2 Mouse ubiquitin/UBB protein Mouse
GM-Tg-cynog-IP11888-Ag-1/ GM-Tg-cynog-IP11888-Ag-2 Cynomolgus/Rhesus macaque ubiquitin/UBB protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP11888-Ag-1/ GM-Tg-felg-IP11888-Ag-2 Feline ubiquitin/UBB protein Feline
GM-Tg-cang-IP11888-Ag-1/ GM-Tg-cang-IP11888-Ag-2 Canine ubiquitin/UBB protein Canine
GM-Tg-bovg-IP11888-Ag-1/ GM-Tg-bovg-IP11888-Ag-2 Bovine ubiquitin/UBB protein Bovine
GM-Tg-equg-IP11888-Ag-1/ GM-Tg-equg-IP11888-Ag-2 Equine ubiquitin/UBB protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP11888-Ag-1/ GM-Tg-hg-IP11888-Ag-2; GM-Tg-rg-IP11888-Ag-1/ GM-Tg-rg-IP11888-Ag-2;
GM-Tg-mg-IP11888-Ag-1/ GM-Tg-mg-IP11888-Ag-2; GM-Tg-cynog-IP11888-Ag-1/ GM-Tg-cynog-IP11888-Ag-2;
GM-Tg-felg-IP11888-Ag-1/ GM-Tg-felg-IP11888-Ag-2; GM-Tg-cang-IP11888-Ag-1/ GM-Tg-cang-IP11888-Ag-2;
GM-Tg-bovg-IP11888-Ag-1/ GM-Tg-bovg-IP11888-Ag-2; GM-Tg-equg-IP11888-Ag-1/ GM-Tg-equg-IP11888-Ag-2
Products Name ubiquitin/UBB protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ubiquitin/UBB
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ubiquitin/UBB protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.