Recombinant multi-species TRAF2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TRAF2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]
The Alternative Names of target: E3 ubiquitin-protein ligase TRAF2,MGC:45012,RING-type E3 ubiquitin transferase TRAF2,RNF117,TNF receptor-associated factor 2,TRAF2,TRAP,TRAP3,Traf2,Tumor necrosis factor type 2 receptor-associated protein 3

Target products collectionGo to TRAF2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP11724-Ag-1/ GM-Tg-hg-IP11724-Ag-2 Human TRAF2 protein Human
GM-Tg-rg-IP11724-Ag-1/ GM-Tg-rg-IP11724-Ag-2 Rat TRAF2 protein Rat
GM-Tg-mg-IP11724-Ag-1/ GM-Tg-mg-IP11724-Ag-2 Mouse TRAF2 protein Mouse
GM-Tg-cynog-IP11724-Ag-1/ GM-Tg-cynog-IP11724-Ag-2 Cynomolgus/Rhesus macaque TRAF2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP11724-Ag-1/ GM-Tg-felg-IP11724-Ag-2 Feline TRAF2 protein Feline
GM-Tg-cang-IP11724-Ag-1/ GM-Tg-cang-IP11724-Ag-2 Canine TRAF2 protein Canine
GM-Tg-bovg-IP11724-Ag-1/ GM-Tg-bovg-IP11724-Ag-2 Bovine TRAF2 protein Bovine
GM-Tg-equg-IP11724-Ag-1/ GM-Tg-equg-IP11724-Ag-2 Equine TRAF2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP11724-Ag-1/ GM-Tg-hg-IP11724-Ag-2; GM-Tg-rg-IP11724-Ag-1/ GM-Tg-rg-IP11724-Ag-2;
GM-Tg-mg-IP11724-Ag-1/ GM-Tg-mg-IP11724-Ag-2; GM-Tg-cynog-IP11724-Ag-1/ GM-Tg-cynog-IP11724-Ag-2;
GM-Tg-felg-IP11724-Ag-1/ GM-Tg-felg-IP11724-Ag-2; GM-Tg-cang-IP11724-Ag-1/ GM-Tg-cang-IP11724-Ag-2;
GM-Tg-bovg-IP11724-Ag-1/ GM-Tg-bovg-IP11724-Ag-2; GM-Tg-equg-IP11724-Ag-1/ GM-Tg-equg-IP11724-Ag-2
Products Name TRAF2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name TRAF2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TRAF2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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