Recombinant multi-species TNNT3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TNNT3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
The Alternative Names of target: Beta-TnTF,DA2B2,Fast skeletal muscle troponin T (fTnT),TNNT3,TNTF,TnTf,Tnnt3,Tnt,Troponin T,beta-TnTF,fTnT,fast skeletal muscle

Target products collectionGo to TNNT3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP11708-Ag-1/ GM-Tg-hg-IP11708-Ag-2 Human TNNT3 protein Human
GM-Tg-rg-IP11708-Ag-1/ GM-Tg-rg-IP11708-Ag-2 Rat TNNT3 protein Rat
GM-Tg-mg-IP11708-Ag-1/ GM-Tg-mg-IP11708-Ag-2 Mouse TNNT3 protein Mouse
GM-Tg-cynog-IP11708-Ag-1/ GM-Tg-cynog-IP11708-Ag-2 Cynomolgus/Rhesus macaque TNNT3 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP11708-Ag-1/ GM-Tg-felg-IP11708-Ag-2 Feline TNNT3 protein Feline
GM-Tg-cang-IP11708-Ag-1/ GM-Tg-cang-IP11708-Ag-2 Canine TNNT3 protein Canine
GM-Tg-bovg-IP11708-Ag-1/ GM-Tg-bovg-IP11708-Ag-2 Bovine TNNT3 protein Bovine
GM-Tg-equg-IP11708-Ag-1/ GM-Tg-equg-IP11708-Ag-2 Equine TNNT3 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP11708-Ag-1/ GM-Tg-hg-IP11708-Ag-2; GM-Tg-rg-IP11708-Ag-1/ GM-Tg-rg-IP11708-Ag-2;
GM-Tg-mg-IP11708-Ag-1/ GM-Tg-mg-IP11708-Ag-2; GM-Tg-cynog-IP11708-Ag-1/ GM-Tg-cynog-IP11708-Ag-2;
GM-Tg-felg-IP11708-Ag-1/ GM-Tg-felg-IP11708-Ag-2; GM-Tg-cang-IP11708-Ag-1/ GM-Tg-cang-IP11708-Ag-2;
GM-Tg-bovg-IP11708-Ag-1/ GM-Tg-bovg-IP11708-Ag-2; GM-Tg-equg-IP11708-Ag-1/ GM-Tg-equg-IP11708-Ag-2
Products Name TNNT3 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name TNNT3
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TNNT3 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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