Recombinant multi-species BRCA1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BRCA1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020]
The Alternative Names of target: BRCA-1,BRCA1,BRCAI,BRCC1,BROVCA1,Brca1,Breast cancer type 1 susceptibility protein,FANCS,IRIS,PNCA4,PPP1R53,PSCP,RING finger protein 53,RING-type E3 ubiquitin transferase BRCA1,RNF53

Target products collectionGo to BRCA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP11553-Ag-1/ GM-Tg-hg-IP11553-Ag-2 Human BRCA1 protein Human
GM-Tg-rg-IP11553-Ag-1/ GM-Tg-rg-IP11553-Ag-2 Rat BRCA1 protein Rat
GM-Tg-mg-IP11553-Ag-1/ GM-Tg-mg-IP11553-Ag-2 Mouse BRCA1 protein Mouse
GM-Tg-cynog-IP11553-Ag-1/ GM-Tg-cynog-IP11553-Ag-2 Cynomolgus/Rhesus macaque BRCA1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP11553-Ag-1/ GM-Tg-felg-IP11553-Ag-2 Feline BRCA1 protein Feline
GM-Tg-cang-IP11553-Ag-1/ GM-Tg-cang-IP11553-Ag-2 Canine BRCA1 protein Canine
GM-Tg-bovg-IP11553-Ag-1/ GM-Tg-bovg-IP11553-Ag-2 Bovine BRCA1 protein Bovine
GM-Tg-equg-IP11553-Ag-1/ GM-Tg-equg-IP11553-Ag-2 Equine BRCA1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP11553-Ag-1/ GM-Tg-hg-IP11553-Ag-2; GM-Tg-rg-IP11553-Ag-1/ GM-Tg-rg-IP11553-Ag-2;
GM-Tg-mg-IP11553-Ag-1/ GM-Tg-mg-IP11553-Ag-2; GM-Tg-cynog-IP11553-Ag-1/ GM-Tg-cynog-IP11553-Ag-2;
GM-Tg-felg-IP11553-Ag-1/ GM-Tg-felg-IP11553-Ag-2; GM-Tg-cang-IP11553-Ag-1/ GM-Tg-cang-IP11553-Ag-2;
GM-Tg-bovg-IP11553-Ag-1/ GM-Tg-bovg-IP11553-Ag-2; GM-Tg-equg-IP11553-Ag-1/ GM-Tg-equg-IP11553-Ag-2
Products Name BRCA1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name BRCA1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BRCA1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.