Recombinant multi-species BCL11B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BCL11B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
The Alternative Names of target: 9130430L19Rik,ATL1,ATL1-alpha,ATL1-beta,ATL1-delta,ATL1-gamma,B-cell CLL/lymphoma 11B,B-cell lymphoma/leukemia 11B,B630002E05Rik,BCL-11B,BCL11B,Bcl11b,COUP-TF-interacting protein 2,CTIP-2,CTIP2,Ctip2,IDDFSTA,IMD49,RIT1,Radiation-induced tumor suppressor gene 1 protein (hRit1),Rit1,SMARCM2,ZNF856B,hRIT1-alpha

Target products collectionGo to BCL11B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP11369-Ag-1/ GM-Tg-hg-IP11369-Ag-2 Human BCL11B protein Human
GM-Tg-rg-IP11369-Ag-1/ GM-Tg-rg-IP11369-Ag-2 Rat BCL11B protein Rat
GM-Tg-mg-IP11369-Ag-1/ GM-Tg-mg-IP11369-Ag-2 Mouse BCL11B protein Mouse
GM-Tg-cynog-IP11369-Ag-1/ GM-Tg-cynog-IP11369-Ag-2 Cynomolgus/Rhesus macaque BCL11B protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP11369-Ag-1/ GM-Tg-felg-IP11369-Ag-2 Feline BCL11B protein Feline
GM-Tg-cang-IP11369-Ag-1/ GM-Tg-cang-IP11369-Ag-2 Canine BCL11B protein Canine
GM-Tg-bovg-IP11369-Ag-1/ GM-Tg-bovg-IP11369-Ag-2 Bovine BCL11B protein Bovine
GM-Tg-equg-IP11369-Ag-1/ GM-Tg-equg-IP11369-Ag-2 Equine BCL11B protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP11369-Ag-1/ GM-Tg-hg-IP11369-Ag-2; GM-Tg-rg-IP11369-Ag-1/ GM-Tg-rg-IP11369-Ag-2;
GM-Tg-mg-IP11369-Ag-1/ GM-Tg-mg-IP11369-Ag-2; GM-Tg-cynog-IP11369-Ag-1/ GM-Tg-cynog-IP11369-Ag-2;
GM-Tg-felg-IP11369-Ag-1/ GM-Tg-felg-IP11369-Ag-2; GM-Tg-cang-IP11369-Ag-1/ GM-Tg-cang-IP11369-Ag-2;
GM-Tg-bovg-IP11369-Ag-1/ GM-Tg-bovg-IP11369-Ag-2; GM-Tg-equg-IP11369-Ag-1/ GM-Tg-equg-IP11369-Ag-2
Products Name BCL11B protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name BCL11B
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BCL11B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.