Recombinant multi-species IFIH1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IFIH1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria infection. In addition to its protective role in antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome[provided by RefSeq, Jul 2020]
The Alternative Names of target: 9130009C22Rik,AGS7,Clinically amyopathic dermatomyositis autoantigen 140 kDa (CADM-140 autoantigen),Helicard,Helicase with 2 CARD domains (Helicard),Hlcd,IDDM19,IFIH1,IMD95,Ifih1,Interferon-induced helicase C domain-containing protein 1,Interferon-induced with helicase C domain protein 1,MDA-5,MDA5,Melanoma differentiation-associated protein 5 (MDA-5),Murabutide down-regulated protein,RGD1560496,RIG-I-like receptor 2 (RLR-2),RLR-2,RNA helicase-DEAD box protein 116,SGMRT1

Target products collectionGo to IFIH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP11112-Ag-1/ GM-Tg-hg-IP11112-Ag-2 Human IFIH1 protein Human
GM-Tg-rg-IP11112-Ag-1/ GM-Tg-rg-IP11112-Ag-2 Rat IFIH1 protein Rat
GM-Tg-mg-IP11112-Ag-1/ GM-Tg-mg-IP11112-Ag-2 Mouse IFIH1 protein Mouse
GM-Tg-cynog-IP11112-Ag-1/ GM-Tg-cynog-IP11112-Ag-2 Cynomolgus/Rhesus macaque IFIH1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP11112-Ag-1/ GM-Tg-felg-IP11112-Ag-2 Feline IFIH1 protein Feline
GM-Tg-cang-IP11112-Ag-1/ GM-Tg-cang-IP11112-Ag-2 Canine IFIH1 protein Canine
GM-Tg-bovg-IP11112-Ag-1/ GM-Tg-bovg-IP11112-Ag-2 Bovine IFIH1 protein Bovine
GM-Tg-equg-IP11112-Ag-1/ GM-Tg-equg-IP11112-Ag-2 Equine IFIH1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP11112-Ag-1/ GM-Tg-hg-IP11112-Ag-2; GM-Tg-rg-IP11112-Ag-1/ GM-Tg-rg-IP11112-Ag-2;
GM-Tg-mg-IP11112-Ag-1/ GM-Tg-mg-IP11112-Ag-2; GM-Tg-cynog-IP11112-Ag-1/ GM-Tg-cynog-IP11112-Ag-2;
GM-Tg-felg-IP11112-Ag-1/ GM-Tg-felg-IP11112-Ag-2; GM-Tg-cang-IP11112-Ag-1/ GM-Tg-cang-IP11112-Ag-2;
GM-Tg-bovg-IP11112-Ag-1/ GM-Tg-bovg-IP11112-Ag-2; GM-Tg-equg-IP11112-Ag-1/ GM-Tg-equg-IP11112-Ag-2
Products Name IFIH1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IFIH1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IFIH1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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