Recombinant multi-species Ataxin 2/ATXN2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Ataxin 2/ATXN2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
The Alternative Names of target: 9630045M23Rik,ATX2,ATXN2,Ataxin 2,Ataxin-2,Atxn2,SCA2,Sca2,Spinocerebellar ataxia type 2 protein,TNRC13,Trinucleotide repeat-containing gene 13 protein,ataxin-2

Target products collectionGo to Ataxin 2/ATXN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP11038-Ag-1/ GM-Tg-hg-IP11038-Ag-2 Human Ataxin 2/ATXN2 protein Human
GM-Tg-rg-IP11038-Ag-1/ GM-Tg-rg-IP11038-Ag-2 Rat Ataxin 2/ATXN2 protein Rat
GM-Tg-mg-IP11038-Ag-1/ GM-Tg-mg-IP11038-Ag-2 Mouse Ataxin 2/ATXN2 protein Mouse
GM-Tg-cynog-IP11038-Ag-1/ GM-Tg-cynog-IP11038-Ag-2 Cynomolgus/Rhesus macaque Ataxin 2/ATXN2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP11038-Ag-1/ GM-Tg-felg-IP11038-Ag-2 Feline Ataxin 2/ATXN2 protein Feline
GM-Tg-cang-IP11038-Ag-1/ GM-Tg-cang-IP11038-Ag-2 Canine Ataxin 2/ATXN2 protein Canine
GM-Tg-bovg-IP11038-Ag-1/ GM-Tg-bovg-IP11038-Ag-2 Bovine Ataxin 2/ATXN2 protein Bovine
GM-Tg-equg-IP11038-Ag-1/ GM-Tg-equg-IP11038-Ag-2 Equine Ataxin 2/ATXN2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP11038-Ag-1/ GM-Tg-hg-IP11038-Ag-2; GM-Tg-rg-IP11038-Ag-1/ GM-Tg-rg-IP11038-Ag-2;
GM-Tg-mg-IP11038-Ag-1/ GM-Tg-mg-IP11038-Ag-2; GM-Tg-cynog-IP11038-Ag-1/ GM-Tg-cynog-IP11038-Ag-2;
GM-Tg-felg-IP11038-Ag-1/ GM-Tg-felg-IP11038-Ag-2; GM-Tg-cang-IP11038-Ag-1/ GM-Tg-cang-IP11038-Ag-2;
GM-Tg-bovg-IP11038-Ag-1/ GM-Tg-bovg-IP11038-Ag-2; GM-Tg-equg-IP11038-Ag-1/ GM-Tg-equg-IP11038-Ag-2
Products Name Ataxin 2/ATXN2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Ataxin 2/ATXN2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Ataxin 2/ATXN2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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