Recombinant multi-species SAFB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SAFB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
The Alternative Names of target: HAP,HET,HSP27 estrogen response element-TATA box-binding protein (HSP27 ERE-TATA-binding protein),SAB-B1,SAF-B,SAF-B1,SAFB,SAFB1,Safb,Scaffold attachment factor B1

Target products collectionGo to SAFB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP11030-Ag-1/ GM-Tg-hg-IP11030-Ag-2 Human SAFB protein Human
GM-Tg-rg-IP11030-Ag-1/ GM-Tg-rg-IP11030-Ag-2 Rat SAFB protein Rat
GM-Tg-mg-IP11030-Ag-1/ GM-Tg-mg-IP11030-Ag-2 Mouse SAFB protein Mouse
GM-Tg-cynog-IP11030-Ag-1/ GM-Tg-cynog-IP11030-Ag-2 Cynomolgus/Rhesus macaque SAFB protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP11030-Ag-1/ GM-Tg-felg-IP11030-Ag-2 Feline SAFB protein Feline
GM-Tg-cang-IP11030-Ag-1/ GM-Tg-cang-IP11030-Ag-2 Canine SAFB protein Canine
GM-Tg-bovg-IP11030-Ag-1/ GM-Tg-bovg-IP11030-Ag-2 Bovine SAFB protein Bovine
GM-Tg-equg-IP11030-Ag-1/ GM-Tg-equg-IP11030-Ag-2 Equine SAFB protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP11030-Ag-1/ GM-Tg-hg-IP11030-Ag-2; GM-Tg-rg-IP11030-Ag-1/ GM-Tg-rg-IP11030-Ag-2;
GM-Tg-mg-IP11030-Ag-1/ GM-Tg-mg-IP11030-Ag-2; GM-Tg-cynog-IP11030-Ag-1/ GM-Tg-cynog-IP11030-Ag-2;
GM-Tg-felg-IP11030-Ag-1/ GM-Tg-felg-IP11030-Ag-2; GM-Tg-cang-IP11030-Ag-1/ GM-Tg-cang-IP11030-Ag-2;
GM-Tg-bovg-IP11030-Ag-1/ GM-Tg-bovg-IP11030-Ag-2; GM-Tg-equg-IP11030-Ag-1/ GM-Tg-equg-IP11030-Ag-2
Products Name SAFB protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SAFB
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SAFB protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.