Recombinant multi-species LMNA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LMNA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is part of the nuclear lamina, a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, May 2022]
The Alternative Names of target: CDCD1,CDDC,CMD1A,CMT2B1,Dhe,EMD2,FPL,FPLD,FPLD2,HGPS,IDC,LDP1,LFP,LGMD1B,LMN1,LMNA,LMNC,LMNL1,Lmna,MADA,PRO1,Prelamin-A/C

Target products collectionGo to LMNA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP1097-Ag-1/ GM-Tg-hg-IP1097-Ag-2 Human LMNA protein Human
GM-Tg-rg-IP1097-Ag-1/ GM-Tg-rg-IP1097-Ag-2 Rat LMNA protein Rat
GM-Tg-mg-IP1097-Ag-1/ GM-Tg-mg-IP1097-Ag-2 Mouse LMNA protein Mouse
GM-Tg-cynog-IP1097-Ag-1/ GM-Tg-cynog-IP1097-Ag-2 Cynomolgus/Rhesus macaque LMNA protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP1097-Ag-1/ GM-Tg-felg-IP1097-Ag-2 Feline LMNA protein Feline
GM-Tg-cang-IP1097-Ag-1/ GM-Tg-cang-IP1097-Ag-2 Canine LMNA protein Canine
GM-Tg-bovg-IP1097-Ag-1/ GM-Tg-bovg-IP1097-Ag-2 Bovine LMNA protein Bovine
GM-Tg-equg-IP1097-Ag-1/ GM-Tg-equg-IP1097-Ag-2 Equine LMNA protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP1097-Ag-1/ GM-Tg-hg-IP1097-Ag-2; GM-Tg-rg-IP1097-Ag-1/ GM-Tg-rg-IP1097-Ag-2;
GM-Tg-mg-IP1097-Ag-1/ GM-Tg-mg-IP1097-Ag-2; GM-Tg-cynog-IP1097-Ag-1/ GM-Tg-cynog-IP1097-Ag-2;
GM-Tg-felg-IP1097-Ag-1/ GM-Tg-felg-IP1097-Ag-2; GM-Tg-cang-IP1097-Ag-1/ GM-Tg-cang-IP1097-Ag-2;
GM-Tg-bovg-IP1097-Ag-1/ GM-Tg-bovg-IP1097-Ag-2; GM-Tg-equg-IP1097-Ag-1/ GM-Tg-equg-IP1097-Ag-2
Products Name LMNA protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name LMNA
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LMNA protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.