Recombinant multi-species SAV1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SAV1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]
The Alternative Names of target: 1700040G09Rik,45 kDa WW domain protein (hWW45),Protein salvador homolog 1,SAV,SAV1,Salv,Sav,Sav1,WW45,WWP4,Wwp3,Wwp4

Target products collectionGo to SAV1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP10922-Ag-1/ GM-Tg-hg-IP10922-Ag-2 Human SAV1 protein Human
GM-Tg-rg-IP10922-Ag-1/ GM-Tg-rg-IP10922-Ag-2 Rat SAV1 protein Rat
GM-Tg-mg-IP10922-Ag-1/ GM-Tg-mg-IP10922-Ag-2 Mouse SAV1 protein Mouse
GM-Tg-cynog-IP10922-Ag-1/ GM-Tg-cynog-IP10922-Ag-2 Cynomolgus/Rhesus macaque SAV1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP10922-Ag-1/ GM-Tg-felg-IP10922-Ag-2 Feline SAV1 protein Feline
GM-Tg-cang-IP10922-Ag-1/ GM-Tg-cang-IP10922-Ag-2 Canine SAV1 protein Canine
GM-Tg-bovg-IP10922-Ag-1/ GM-Tg-bovg-IP10922-Ag-2 Bovine SAV1 protein Bovine
GM-Tg-equg-IP10922-Ag-1/ GM-Tg-equg-IP10922-Ag-2 Equine SAV1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP10922-Ag-1/ GM-Tg-hg-IP10922-Ag-2; GM-Tg-rg-IP10922-Ag-1/ GM-Tg-rg-IP10922-Ag-2;
GM-Tg-mg-IP10922-Ag-1/ GM-Tg-mg-IP10922-Ag-2; GM-Tg-cynog-IP10922-Ag-1/ GM-Tg-cynog-IP10922-Ag-2;
GM-Tg-felg-IP10922-Ag-1/ GM-Tg-felg-IP10922-Ag-2; GM-Tg-cang-IP10922-Ag-1/ GM-Tg-cang-IP10922-Ag-2;
GM-Tg-bovg-IP10922-Ag-1/ GM-Tg-bovg-IP10922-Ag-2; GM-Tg-equg-IP10922-Ag-1/ GM-Tg-equg-IP10922-Ag-2
Products Name SAV1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SAV1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SAV1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.