Recombinant multi-species RAN protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RAN protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
The Alternative Names of target: ARA24,Androgen receptor-associated protein 24,GTP-binding nuclear protein Ran,GTPase Ran,Gsp1,RAN,Ran,Ras-like protein TC4,Ras-related nuclear protein,TC4

Target products collectionGo to RAN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP10845-Ag-1/ GM-Tg-hg-IP10845-Ag-2 Human RAN protein Human
GM-Tg-rg-IP10845-Ag-1/ GM-Tg-rg-IP10845-Ag-2 Rat RAN protein Rat
GM-Tg-mg-IP10845-Ag-1/ GM-Tg-mg-IP10845-Ag-2 Mouse RAN protein Mouse
GM-Tg-cynog-IP10845-Ag-1/ GM-Tg-cynog-IP10845-Ag-2 Cynomolgus/Rhesus macaque RAN protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP10845-Ag-1/ GM-Tg-felg-IP10845-Ag-2 Feline RAN protein Feline
GM-Tg-cang-IP10845-Ag-1/ GM-Tg-cang-IP10845-Ag-2 Canine RAN protein Canine
GM-Tg-bovg-IP10845-Ag-1/ GM-Tg-bovg-IP10845-Ag-2 Bovine RAN protein Bovine
GM-Tg-equg-IP10845-Ag-1/ GM-Tg-equg-IP10845-Ag-2 Equine RAN protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP10845-Ag-1/ GM-Tg-hg-IP10845-Ag-2; GM-Tg-rg-IP10845-Ag-1/ GM-Tg-rg-IP10845-Ag-2;
GM-Tg-mg-IP10845-Ag-1/ GM-Tg-mg-IP10845-Ag-2; GM-Tg-cynog-IP10845-Ag-1/ GM-Tg-cynog-IP10845-Ag-2;
GM-Tg-felg-IP10845-Ag-1/ GM-Tg-felg-IP10845-Ag-2; GM-Tg-cang-IP10845-Ag-1/ GM-Tg-cang-IP10845-Ag-2;
GM-Tg-bovg-IP10845-Ag-1/ GM-Tg-bovg-IP10845-Ag-2; GM-Tg-equg-IP10845-Ag-1/ GM-Tg-equg-IP10845-Ag-2
Products Name RAN protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name RAN
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RAN protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.