Recombinant multi-species RAG2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RAG2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]
The Alternative Names of target: RAG-2,RAG2,Rag-2,Rag2,V(D)J recombination-activating protein 2

Target products collectionGo to RAG2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP10841-Ag-1/ GM-Tg-hg-IP10841-Ag-2 Human RAG2 protein Human
GM-Tg-rg-IP10841-Ag-1/ GM-Tg-rg-IP10841-Ag-2 Rat RAG2 protein Rat
GM-Tg-mg-IP10841-Ag-1/ GM-Tg-mg-IP10841-Ag-2 Mouse RAG2 protein Mouse
GM-Tg-cynog-IP10841-Ag-1/ GM-Tg-cynog-IP10841-Ag-2 Cynomolgus/Rhesus macaque RAG2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP10841-Ag-1/ GM-Tg-felg-IP10841-Ag-2 Feline RAG2 protein Feline
GM-Tg-cang-IP10841-Ag-1/ GM-Tg-cang-IP10841-Ag-2 Canine RAG2 protein Canine
GM-Tg-bovg-IP10841-Ag-1/ GM-Tg-bovg-IP10841-Ag-2 Bovine RAG2 protein Bovine
GM-Tg-equg-IP10841-Ag-1/ GM-Tg-equg-IP10841-Ag-2 Equine RAG2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP10841-Ag-1/ GM-Tg-hg-IP10841-Ag-2; GM-Tg-rg-IP10841-Ag-1/ GM-Tg-rg-IP10841-Ag-2;
GM-Tg-mg-IP10841-Ag-1/ GM-Tg-mg-IP10841-Ag-2; GM-Tg-cynog-IP10841-Ag-1/ GM-Tg-cynog-IP10841-Ag-2;
GM-Tg-felg-IP10841-Ag-1/ GM-Tg-felg-IP10841-Ag-2; GM-Tg-cang-IP10841-Ag-1/ GM-Tg-cang-IP10841-Ag-2;
GM-Tg-bovg-IP10841-Ag-1/ GM-Tg-bovg-IP10841-Ag-2; GM-Tg-equg-IP10841-Ag-1/ GM-Tg-equg-IP10841-Ag-2
Products Name RAG2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name RAG2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RAG2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.