Recombinant multi-species PSME1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PSME1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
The Alternative Names of target: 11S regulator complex subunit alpha (REG-alpha),Activator of multicatalytic protease subunit 1,HEL-S-129m,IFI5111,Interferon gamma up-regulated I-5111 protein (IGUP I-5111),PA28A,PA28a,PA28alpha,PA28alpha),PSME1,Proteasome activator 28 subunit alpha (PA28a,Proteasome activator complex subunit 1,Psme1,REGalpha

Target products collectionGo to PSME1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP10565-Ag-1/ GM-Tg-hg-IP10565-Ag-2 Human PSME1 protein Human
GM-Tg-rg-IP10565-Ag-1/ GM-Tg-rg-IP10565-Ag-2 Rat PSME1 protein Rat
GM-Tg-mg-IP10565-Ag-1/ GM-Tg-mg-IP10565-Ag-2 Mouse PSME1 protein Mouse
GM-Tg-cynog-IP10565-Ag-1/ GM-Tg-cynog-IP10565-Ag-2 Cynomolgus/Rhesus macaque PSME1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP10565-Ag-1/ GM-Tg-felg-IP10565-Ag-2 Feline PSME1 protein Feline
GM-Tg-cang-IP10565-Ag-1/ GM-Tg-cang-IP10565-Ag-2 Canine PSME1 protein Canine
GM-Tg-bovg-IP10565-Ag-1/ GM-Tg-bovg-IP10565-Ag-2 Bovine PSME1 protein Bovine
GM-Tg-equg-IP10565-Ag-1/ GM-Tg-equg-IP10565-Ag-2 Equine PSME1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP10565-Ag-1/ GM-Tg-hg-IP10565-Ag-2; GM-Tg-rg-IP10565-Ag-1/ GM-Tg-rg-IP10565-Ag-2;
GM-Tg-mg-IP10565-Ag-1/ GM-Tg-mg-IP10565-Ag-2; GM-Tg-cynog-IP10565-Ag-1/ GM-Tg-cynog-IP10565-Ag-2;
GM-Tg-felg-IP10565-Ag-1/ GM-Tg-felg-IP10565-Ag-2; GM-Tg-cang-IP10565-Ag-1/ GM-Tg-cang-IP10565-Ag-2;
GM-Tg-bovg-IP10565-Ag-1/ GM-Tg-bovg-IP10565-Ag-2; GM-Tg-equg-IP10565-Ag-1/ GM-Tg-equg-IP10565-Ag-2
Products Name PSME1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PSME1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PSME1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.