Recombinant multi-species MAP2K3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MAP2K3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
The Alternative Names of target: Dual specificity mitogen-activated protein kinase kinase 3,MAP kinase kinase 3,MAP2K3,MAPK/ERK kinase 3 (MEK 3),MAPKK 3,MAPKK3,MEK3,MKK3,MKK3b,Map2k3,Mek3,Mkk3,PRKMK3,Prkmk3,SAPKK-2,SAPKK2,SAPKK2),Stress-activated protein kinase kinase 2 (SAPK kinase 2

Target products collectionGo to MAP2K3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP10374-Ag-1/ GM-Tg-hg-IP10374-Ag-2 Human MAP2K3 protein Human
GM-Tg-rg-IP10374-Ag-1/ GM-Tg-rg-IP10374-Ag-2 Rat MAP2K3 protein Rat
GM-Tg-mg-IP10374-Ag-1/ GM-Tg-mg-IP10374-Ag-2 Mouse MAP2K3 protein Mouse
GM-Tg-cynog-IP10374-Ag-1/ GM-Tg-cynog-IP10374-Ag-2 Cynomolgus/Rhesus macaque MAP2K3 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP10374-Ag-1/ GM-Tg-felg-IP10374-Ag-2 Feline MAP2K3 protein Feline
GM-Tg-cang-IP10374-Ag-1/ GM-Tg-cang-IP10374-Ag-2 Canine MAP2K3 protein Canine
GM-Tg-bovg-IP10374-Ag-1/ GM-Tg-bovg-IP10374-Ag-2 Bovine MAP2K3 protein Bovine
GM-Tg-equg-IP10374-Ag-1/ GM-Tg-equg-IP10374-Ag-2 Equine MAP2K3 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP10374-Ag-1/ GM-Tg-hg-IP10374-Ag-2; GM-Tg-rg-IP10374-Ag-1/ GM-Tg-rg-IP10374-Ag-2;
GM-Tg-mg-IP10374-Ag-1/ GM-Tg-mg-IP10374-Ag-2; GM-Tg-cynog-IP10374-Ag-1/ GM-Tg-cynog-IP10374-Ag-2;
GM-Tg-felg-IP10374-Ag-1/ GM-Tg-felg-IP10374-Ag-2; GM-Tg-cang-IP10374-Ag-1/ GM-Tg-cang-IP10374-Ag-2;
GM-Tg-bovg-IP10374-Ag-1/ GM-Tg-bovg-IP10374-Ag-2; GM-Tg-equg-IP10374-Ag-1/ GM-Tg-equg-IP10374-Ag-2
Products Name MAP2K3 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MAP2K3
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MAP2K3 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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