Recombinant multi-species PRKACA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PRKACA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]
The Alternative Names of target: CAFD1,Cs-PKA,PKA,PKA C-alpha,PKACA,PKCA1,PKCD,PPNAD4,PRKACA,Pkaca,Prkaca,cAMP-dependent protein kinase catalytic subunit alpha

Target products collectionGo to PRKACA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP10225-Ag-1/ GM-Tg-hg-IP10225-Ag-2 Human PRKACA protein Human
GM-Tg-rg-IP10225-Ag-1/ GM-Tg-rg-IP10225-Ag-2 Rat PRKACA protein Rat
GM-Tg-mg-IP10225-Ag-1/ GM-Tg-mg-IP10225-Ag-2 Mouse PRKACA protein Mouse
GM-Tg-cynog-IP10225-Ag-1/ GM-Tg-cynog-IP10225-Ag-2 Cynomolgus/Rhesus macaque PRKACA protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP10225-Ag-1/ GM-Tg-felg-IP10225-Ag-2 Feline PRKACA protein Feline
GM-Tg-cang-IP10225-Ag-1/ GM-Tg-cang-IP10225-Ag-2 Canine PRKACA protein Canine
GM-Tg-bovg-IP10225-Ag-1/ GM-Tg-bovg-IP10225-Ag-2 Bovine PRKACA protein Bovine
GM-Tg-equg-IP10225-Ag-1/ GM-Tg-equg-IP10225-Ag-2 Equine PRKACA protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP10225-Ag-1/ GM-Tg-hg-IP10225-Ag-2; GM-Tg-rg-IP10225-Ag-1/ GM-Tg-rg-IP10225-Ag-2;
GM-Tg-mg-IP10225-Ag-1/ GM-Tg-mg-IP10225-Ag-2; GM-Tg-cynog-IP10225-Ag-1/ GM-Tg-cynog-IP10225-Ag-2;
GM-Tg-felg-IP10225-Ag-1/ GM-Tg-felg-IP10225-Ag-2; GM-Tg-cang-IP10225-Ag-1/ GM-Tg-cang-IP10225-Ag-2;
GM-Tg-bovg-IP10225-Ag-1/ GM-Tg-bovg-IP10225-Ag-2; GM-Tg-equg-IP10225-Ag-1/ GM-Tg-equg-IP10225-Ag-2
Products Name PRKACA protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PRKACA
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PRKACA protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.