Recombinant multi-species IKZF1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IKZF1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
The Alternative Names of target: 5832432G11Rik,CVID13,DNA-binding protein Ikaros,Hs.54452,IK1,IKAROS,IKZF1,Ikaros,Ikaros family zinc finger protein 1,Ikzf1,LYF1,LyF-1,Lymphoid transcription factor LyF-1,PPP1R92,PRO0758,RGD1562979,ZNFN1A1,Zfpn1a1,Znfn1a1,hlk-1,mKIAA4227

Target products collectionGo to IKZF1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP1008-Ag-1/ GM-Tg-hg-IP1008-Ag-2 Human IKZF1 protein Human
GM-Tg-rg-IP1008-Ag-1/ GM-Tg-rg-IP1008-Ag-2 Rat IKZF1 protein Rat
GM-Tg-mg-IP1008-Ag-1/ GM-Tg-mg-IP1008-Ag-2 Mouse IKZF1 protein Mouse
GM-Tg-cynog-IP1008-Ag-1/ GM-Tg-cynog-IP1008-Ag-2 Cynomolgus/Rhesus macaque IKZF1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP1008-Ag-1/ GM-Tg-felg-IP1008-Ag-2 Feline IKZF1 protein Feline
GM-Tg-cang-IP1008-Ag-1/ GM-Tg-cang-IP1008-Ag-2 Canine IKZF1 protein Canine
GM-Tg-bovg-IP1008-Ag-1/ GM-Tg-bovg-IP1008-Ag-2 Bovine IKZF1 protein Bovine
GM-Tg-equg-IP1008-Ag-1/ GM-Tg-equg-IP1008-Ag-2 Equine IKZF1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP1008-Ag-1/ GM-Tg-hg-IP1008-Ag-2; GM-Tg-rg-IP1008-Ag-1/ GM-Tg-rg-IP1008-Ag-2;
GM-Tg-mg-IP1008-Ag-1/ GM-Tg-mg-IP1008-Ag-2; GM-Tg-cynog-IP1008-Ag-1/ GM-Tg-cynog-IP1008-Ag-2;
GM-Tg-felg-IP1008-Ag-1/ GM-Tg-felg-IP1008-Ag-2; GM-Tg-cang-IP1008-Ag-1/ GM-Tg-cang-IP1008-Ag-2;
GM-Tg-bovg-IP1008-Ag-1/ GM-Tg-bovg-IP1008-Ag-2; GM-Tg-equg-IP1008-Ag-1/ GM-Tg-equg-IP1008-Ag-2
Products Name IKZF1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IKZF1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IKZF1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.