Recombinant multi-species ATRX protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATRX protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
The Alternative Names of target: 4833408C14Rik,ATP-dependent helicase ATRX,ATR2,ATRX,Atrx,DXHXS6677E,HP1-BP38,Hp1bp2,Hp1bp38,JMS,MRX52,MRXS3,RAD54,RAD54L,Rad54,Transcriptional regulator ATRX,X-linked helicase II,X-linked nuclear protein (XNP),XH2,XNP,Xnp,ZNF-HX,Znf-HX

Target products collectionGo to ATRX products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0396-Ag-1/ GM-Tg-hg-IP0396-Ag-2 Human ATRX protein Human
GM-Tg-rg-IP0396-Ag-1/ GM-Tg-rg-IP0396-Ag-2 Rat ATRX protein Rat
GM-Tg-mg-IP0396-Ag-1/ GM-Tg-mg-IP0396-Ag-2 Mouse ATRX protein Mouse
GM-Tg-cynog-IP0396-Ag-1/ GM-Tg-cynog-IP0396-Ag-2 Cynomolgus/Rhesus macaque ATRX protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0396-Ag-1/ GM-Tg-felg-IP0396-Ag-2 Feline ATRX protein Feline
GM-Tg-cang-IP0396-Ag-1/ GM-Tg-cang-IP0396-Ag-2 Canine ATRX protein Canine
GM-Tg-bovg-IP0396-Ag-1/ GM-Tg-bovg-IP0396-Ag-2 Bovine ATRX protein Bovine
GM-Tg-equg-IP0396-Ag-1/ GM-Tg-equg-IP0396-Ag-2 Equine ATRX protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0396-Ag-1/ GM-Tg-hg-IP0396-Ag-2; GM-Tg-rg-IP0396-Ag-1/ GM-Tg-rg-IP0396-Ag-2;
GM-Tg-mg-IP0396-Ag-1/ GM-Tg-mg-IP0396-Ag-2; GM-Tg-cynog-IP0396-Ag-1/ GM-Tg-cynog-IP0396-Ag-2;
GM-Tg-felg-IP0396-Ag-1/ GM-Tg-felg-IP0396-Ag-2; GM-Tg-cang-IP0396-Ag-1/ GM-Tg-cang-IP0396-Ag-2;
GM-Tg-bovg-IP0396-Ag-1/ GM-Tg-bovg-IP0396-Ag-2; GM-Tg-equg-IP0396-Ag-1/ GM-Tg-equg-IP0396-Ag-2
Products Name ATRX protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ATRX
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATRX protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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