Recombinant multi-species ATF6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATF6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
The Alternative Names of target: 9130025P16Rik,9630036G24,ACHM7,ATF6,ATF6A,ATP6alpha,Activating transcription factor 6 alpha (ATF6-alpha),Atf6,Atf6alpha,Cyclic AMP-dependent transcription factor ATF-6 alpha,ESTM49,cAMP-dependent transcription factor ATF-6 alpha

Target products collectionGo to ATF6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0375-Ag-1/ GM-Tg-hg-IP0375-Ag-2 Human ATF6 protein Human
GM-Tg-rg-IP0375-Ag-1/ GM-Tg-rg-IP0375-Ag-2 Rat ATF6 protein Rat
GM-Tg-mg-IP0375-Ag-1/ GM-Tg-mg-IP0375-Ag-2 Mouse ATF6 protein Mouse
GM-Tg-cynog-IP0375-Ag-1/ GM-Tg-cynog-IP0375-Ag-2 Cynomolgus/Rhesus macaque ATF6 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0375-Ag-1/ GM-Tg-felg-IP0375-Ag-2 Feline ATF6 protein Feline
GM-Tg-cang-IP0375-Ag-1/ GM-Tg-cang-IP0375-Ag-2 Canine ATF6 protein Canine
GM-Tg-bovg-IP0375-Ag-1/ GM-Tg-bovg-IP0375-Ag-2 Bovine ATF6 protein Bovine
GM-Tg-equg-IP0375-Ag-1/ GM-Tg-equg-IP0375-Ag-2 Equine ATF6 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0375-Ag-1/ GM-Tg-hg-IP0375-Ag-2; GM-Tg-rg-IP0375-Ag-1/ GM-Tg-rg-IP0375-Ag-2;
GM-Tg-mg-IP0375-Ag-1/ GM-Tg-mg-IP0375-Ag-2; GM-Tg-cynog-IP0375-Ag-1/ GM-Tg-cynog-IP0375-Ag-2;
GM-Tg-felg-IP0375-Ag-1/ GM-Tg-felg-IP0375-Ag-2; GM-Tg-cang-IP0375-Ag-1/ GM-Tg-cang-IP0375-Ag-2;
GM-Tg-bovg-IP0375-Ag-1/ GM-Tg-bovg-IP0375-Ag-2; GM-Tg-equg-IP0375-Ag-1/ GM-Tg-equg-IP0375-Ag-2
Products Name ATF6 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ATF6
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATF6 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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