Recombinant multi-species FBXW7/Fbxw7 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FBXW7/Fbxw7 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
The Alternative Names of target: 1110001A17Rik,AGO,Archipelago homolog (hAgo),CDC4,Cdc4,DEDHIL,F-box and WD-40 domain-containing protein 7,F-box protein FBX30,F-box/WD repeat-containing protein 7,FBW6,FBW7,FBX30,FBXO30,FBXW6,FBXW7,Fbw7,Fbwd6,Fbx30,Fbxo30,Fbxw6,Fbxw7,SEL-10,SEL10,hAgo,hCdc4

Target products collectionGo to FBXW7/Fbxw7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0208-Ag-1/ GM-Tg-hg-IP0208-Ag-2 Human FBXW7/Fbxw7 protein Human
GM-Tg-rg-IP0208-Ag-1/ GM-Tg-rg-IP0208-Ag-2 Rat FBXW7/Fbxw7 protein Rat
GM-Tg-mg-IP0208-Ag-1/ GM-Tg-mg-IP0208-Ag-2 Mouse FBXW7/Fbxw7 protein Mouse
GM-Tg-cynog-IP0208-Ag-1/ GM-Tg-cynog-IP0208-Ag-2 Cynomolgus/Rhesus macaque FBXW7/Fbxw7 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0208-Ag-1/ GM-Tg-felg-IP0208-Ag-2 Feline FBXW7/Fbxw7 protein Feline
GM-Tg-cang-IP0208-Ag-1/ GM-Tg-cang-IP0208-Ag-2 Canine FBXW7/Fbxw7 protein Canine
GM-Tg-bovg-IP0208-Ag-1/ GM-Tg-bovg-IP0208-Ag-2 Bovine FBXW7/Fbxw7 protein Bovine
GM-Tg-equg-IP0208-Ag-1/ GM-Tg-equg-IP0208-Ag-2 Equine FBXW7/Fbxw7 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0208-Ag-1/ GM-Tg-hg-IP0208-Ag-2; GM-Tg-rg-IP0208-Ag-1/ GM-Tg-rg-IP0208-Ag-2;
GM-Tg-mg-IP0208-Ag-1/ GM-Tg-mg-IP0208-Ag-2; GM-Tg-cynog-IP0208-Ag-1/ GM-Tg-cynog-IP0208-Ag-2;
GM-Tg-felg-IP0208-Ag-1/ GM-Tg-felg-IP0208-Ag-2; GM-Tg-cang-IP0208-Ag-1/ GM-Tg-cang-IP0208-Ag-2;
GM-Tg-bovg-IP0208-Ag-1/ GM-Tg-bovg-IP0208-Ag-2; GM-Tg-equg-IP0208-Ag-1/ GM-Tg-equg-IP0208-Ag-2
Products Name FBXW7/Fbxw7 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name FBXW7/Fbxw7
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FBXW7/Fbxw7 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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