Recombinant multi-species TNK1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TNK1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
The Alternative Names of target: TNK1,Non-receptor tyrosine-protein kinase TNK1,CD38 negative kinase 1,KOS1

Target products collectionGo to TNK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0190-Ab-1/ GM-Tg-hg-IP0190-Ab-2 Human TNK1 protein Human
GM-Tg-rg-IP0190-Ab-1/ GM-Tg-rg-IP0190-Ab-2 Rat TNK1 protein Rat
GM-Tg-mg-IP0190-Ab-1/ GM-Tg-mg-IP0190-Ab-2 Mouse TNK1 protein Mouse
GM-Tg-cynog-IP0190-Ab-1/ GM-Tg-cynog-IP0190-Ab-2 Cynomolgus/Rhesus macaque TNK1 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0190-Ab-1/ GM-Tg-felg-IP0190-Ab-2 Feline TNK1 protein Feline
GM-Tg-cang-IP0190-Ab-1/ GM-Tg-cang-IP0190-Ab-2 Canine TNK1 protein Canine
GM-Tg-bovg-IP0190-Ab-1/ GM-Tg-bovg-IP0190-Ab-2 Bovine TNK1 protein Bovine
GM-Tg-equg-IP0190-Ab-1/ GM-Tg-equg-IP0190-Ab-2 Equine TNK1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0190-Ab-1/ GM-Tg-hg-IP0190-Ab-2; GM-Tg-rg-IP0190-Ab-1/ GM-Tg-rg-IP0190-Ab-2;
GM-Tg-mg-IP0190-Ab-1/ GM-Tg-mg-IP0190-Ab-2; GM-Tg-cynog-IP0190-Ab-1/ GM-Tg-cynog-IP0190-Ab-2;
GM-Tg-felg-IP0190-Ab-1/ GM-Tg-felg-IP0190-Ab-2; GM-Tg-cang-IP0190-Ab-1/ GM-Tg-cang-IP0190-Ab-2;
GM-Tg-bovg-IP0190-Ab-1/ GM-Tg-bovg-IP0190-Ab-2; GM-Tg-equg-IP0190-Ab-1/ GM-Tg-equg-IP0190-Ab-2
Products Name TNK1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name TNK1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TNK1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.