Recombinant multi-species SREBF1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SREBF1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
The Alternative Names of target: ADD-1,ADD1,Class D basic helix-loop-helix protein 1 (bHLHd1),HMD,IFAP2,SREBF1,SREBP-1,SREBP-1c,SREBP1,Srebf1,Srebp1,Sterol regulatory element-binding protein 1,Sterol regulatory element-binding transcription factor 1,bHLHd1

Target products collectionGo to SREBF1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0182-Ag-1/ GM-Tg-hg-IP0182-Ag-2 Human SREBF1 protein Human
GM-Tg-rg-IP0182-Ag-1/ GM-Tg-rg-IP0182-Ag-2 Rat SREBF1 protein Rat
GM-Tg-mg-IP0182-Ag-1/ GM-Tg-mg-IP0182-Ag-2 Mouse SREBF1 protein Mouse
GM-Tg-cynog-IP0182-Ag-1/ GM-Tg-cynog-IP0182-Ag-2 Cynomolgus/Rhesus macaque SREBF1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0182-Ag-1/ GM-Tg-felg-IP0182-Ag-2 Feline SREBF1 protein Feline
GM-Tg-cang-IP0182-Ag-1/ GM-Tg-cang-IP0182-Ag-2 Canine SREBF1 protein Canine
GM-Tg-bovg-IP0182-Ag-1/ GM-Tg-bovg-IP0182-Ag-2 Bovine SREBF1 protein Bovine
GM-Tg-equg-IP0182-Ag-1/ GM-Tg-equg-IP0182-Ag-2 Equine SREBF1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0182-Ag-1/ GM-Tg-hg-IP0182-Ag-2; GM-Tg-rg-IP0182-Ag-1/ GM-Tg-rg-IP0182-Ag-2;
GM-Tg-mg-IP0182-Ag-1/ GM-Tg-mg-IP0182-Ag-2; GM-Tg-cynog-IP0182-Ag-1/ GM-Tg-cynog-IP0182-Ag-2;
GM-Tg-felg-IP0182-Ag-1/ GM-Tg-felg-IP0182-Ag-2; GM-Tg-cang-IP0182-Ag-1/ GM-Tg-cang-IP0182-Ag-2;
GM-Tg-bovg-IP0182-Ag-1/ GM-Tg-bovg-IP0182-Ag-2; GM-Tg-equg-IP0182-Ag-1/ GM-Tg-equg-IP0182-Ag-2
Products Name SREBF1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SREBF1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SREBF1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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