Recombinant multi-species NSD1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NSD1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Sep 2018]
The Alternative Names of target: ARA267,Androgen receptor coactivator 267 kDa protein,Androgen receptor-associated protein of 267 kDa,H3 lysine-36 specific,H3-K36-HMTase,Histone-lysine N-methyltransferase,KMT3B,Lysine N-methyltransferase 3B,NSD1,Nsd1,Nuclear receptor-binding SET domain-containing protein 1 (NR-binding SET domain-containing protein),SOTOS,SOTOS1,STO

Target products collectionGo to NSD1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0132-Ag-1/ GM-Tg-hg-IP0132-Ag-2 Human NSD1 protein Human
GM-Tg-rg-IP0132-Ag-1/ GM-Tg-rg-IP0132-Ag-2 Rat NSD1 protein Rat
GM-Tg-mg-IP0132-Ag-1/ GM-Tg-mg-IP0132-Ag-2 Mouse NSD1 protein Mouse
GM-Tg-cynog-IP0132-Ag-1/ GM-Tg-cynog-IP0132-Ag-2 Cynomolgus/Rhesus macaque NSD1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0132-Ag-1/ GM-Tg-felg-IP0132-Ag-2 Feline NSD1 protein Feline
GM-Tg-cang-IP0132-Ag-1/ GM-Tg-cang-IP0132-Ag-2 Canine NSD1 protein Canine
GM-Tg-bovg-IP0132-Ag-1/ GM-Tg-bovg-IP0132-Ag-2 Bovine NSD1 protein Bovine
GM-Tg-equg-IP0132-Ag-1/ GM-Tg-equg-IP0132-Ag-2 Equine NSD1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0132-Ag-1/ GM-Tg-hg-IP0132-Ag-2; GM-Tg-rg-IP0132-Ag-1/ GM-Tg-rg-IP0132-Ag-2;
GM-Tg-mg-IP0132-Ag-1/ GM-Tg-mg-IP0132-Ag-2; GM-Tg-cynog-IP0132-Ag-1/ GM-Tg-cynog-IP0132-Ag-2;
GM-Tg-felg-IP0132-Ag-1/ GM-Tg-felg-IP0132-Ag-2; GM-Tg-cang-IP0132-Ag-1/ GM-Tg-cang-IP0132-Ag-2;
GM-Tg-bovg-IP0132-Ag-1/ GM-Tg-bovg-IP0132-Ag-2; GM-Tg-equg-IP0132-Ag-1/ GM-Tg-equg-IP0132-Ag-2
Products Name NSD1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name NSD1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NSD1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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