Recombinant multi-species PTK2B/PYK2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PTK2B/PYK2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The Alternative Names of target: CADTK,CAK beta,CAKB,CAKB),CAKbeta,Calcium-dependent tyrosine kinase (CADTK),Calcium-regulated non-receptor proline-rich tyrosine kinase,Cell adhesion kinase beta (CAK-beta,E430023O05Rik,FADK2,FAK2,Focal adhesion kinase 2 (FADK 2),PKB,PTK,PTK2B,PYK2,Proline-rich tyrosine kinase 2,Protein-tyrosine kinase 2-beta,Ptk2b,Pyk2,RAFTK,Raftk,Related adhesion focal tyrosine kinase (RAFTK)

Target products collectionGo to PTK2B/PYK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP0111-Ag-1/ GM-Tg-hg-IP0111-Ag-2 Human PTK2B/PYK2 protein Human
GM-Tg-rg-IP0111-Ag-1/ GM-Tg-rg-IP0111-Ag-2 Rat PTK2B/PYK2 protein Rat
GM-Tg-mg-IP0111-Ag-1/ GM-Tg-mg-IP0111-Ag-2 Mouse PTK2B/PYK2 protein Mouse
GM-Tg-cynog-IP0111-Ag-1/ GM-Tg-cynog-IP0111-Ag-2 Cynomolgus/Rhesus macaque PTK2B/PYK2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP0111-Ag-1/ GM-Tg-felg-IP0111-Ag-2 Feline PTK2B/PYK2 protein Feline
GM-Tg-cang-IP0111-Ag-1/ GM-Tg-cang-IP0111-Ag-2 Canine PTK2B/PYK2 protein Canine
GM-Tg-bovg-IP0111-Ag-1/ GM-Tg-bovg-IP0111-Ag-2 Bovine PTK2B/PYK2 protein Bovine
GM-Tg-equg-IP0111-Ag-1/ GM-Tg-equg-IP0111-Ag-2 Equine PTK2B/PYK2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP0111-Ag-1/ GM-Tg-hg-IP0111-Ag-2; GM-Tg-rg-IP0111-Ag-1/ GM-Tg-rg-IP0111-Ag-2;
GM-Tg-mg-IP0111-Ag-1/ GM-Tg-mg-IP0111-Ag-2; GM-Tg-cynog-IP0111-Ag-1/ GM-Tg-cynog-IP0111-Ag-2;
GM-Tg-felg-IP0111-Ag-1/ GM-Tg-felg-IP0111-Ag-2; GM-Tg-cang-IP0111-Ag-1/ GM-Tg-cang-IP0111-Ag-2;
GM-Tg-bovg-IP0111-Ag-1/ GM-Tg-bovg-IP0111-Ag-2; GM-Tg-equg-IP0111-Ag-1/ GM-Tg-equg-IP0111-Ag-2
Products Name PTK2B/PYK2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PTK2B/PYK2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PTK2B/PYK2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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